经典型Sweet综合征^(18)F-FDG PET/CT多脏器异常显像1例  

Classical Sweet syndrome with multiple organ lesions by ^(18)F-FDG PET/CT:A case report

作　　者：陈钊 邱永康 康磊[1] CHEN Zhao;QIU Yongkang;KANG Lei(Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《北京大学学报(医学版)》2025年第2期403-407,共5页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金(82171970、81871385);北京大学临床医学+X青年专项(PKU2021LCXQ023)-中央高校基本科研业务费;中国科学院过程工程研究所生化工程国家重点实验室开放基金(2020KF-01)。

摘　　要：Sweet综合征,又称急性发热性中性粒细胞性皮肤病,是一种罕见的可累及全身的炎性疾病,临床特征为突然出现的压痛性红色丘疹、斑块或结节,常同时伴有发热、中性粒细胞增多。其发病机制尚未明确,起病与多种感染、自身免疫性疾病、恶性肿瘤以及多种药物的应用有关。根据病因不同,Sweet综合征可分为经典型(又称特发型)、恶性肿瘤相关型、药物相关型3种亚型。Sweet syndrome(acute febrile neutrophilic dermatosis)is a relatively rare inflammatory di-sease,which is characterized by the sudden appearance of tender erythematous skin lesions,often accompanied by pyrexia and elevated neutrophil count.The pathogenesis is not clear yet.Recently,multiple studies have found the association between Sweet syndrome and infections,autoimmune diseases,malignant tumors and the application of multiple drugs.According to different causes,Sweet syndrome can be divided into three types:classical(or idiopathic)Sweet syndrome,malignancy-associated Sweet syndrome and drug-induced Sweet syndrome.Classical Sweet syndrome usually presents in women between the age of 30 to 50 years and may be related to infection,inflammatory bowel disease,or pregnancy.The clinical symptoms typically respond promptly after corticosteroid therapy.The major diagnostic criteria of classical Sweet syndrome include sudden painful erythematous skin lesions,histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis;minor criteria include pyrexia over 38℃,association with hematologic or visceral malignancies,inflammatory diseases,pregnancy or preceded by infection,prompt response to systemic glucocorticoid or potassium iodide treatment,abnormal laboratory values(three of four:erythrocyte sedimentation rate>20 mm/h,positive C-reactive protein,>8.0×10^(9)/L leukocytes,>70% neutrophils).The presence of both major criteria and two of the four minor criteria are required to diagnose classical Sweet syndrome.As for the malignancy-associated Sweet syndrome,skin lesions can be found precede,follow,or at the same time with the diagnosis of hematologic malignancy or a solid tumor.At present,^(18)F-fluorodeoxyglucose(^(18)F-FDG)is commonly used as a positron emission tomography computed tomography(PET/CT)imaging agent for diagnosing and screening malignant tumors.Therefore,most of the case reports on the ^(18)F-FDG PET/CT manifestations of Sweet syndrome are malignancy-associated

关 键 词：SWEET综合征 正电子发射断层显像计算机体层摄影术 诊断 

分 类 号：R814.42[医药卫生—影像医学与核医学]