支原体感染对成人肺功能及呼出气一氧化氮的影响  

Impact of Mycoplasma infection on pulmonary function and fractional exhaled nitric oxide in adults

作　　者：张如岗 殷悦 李岱云 段梦琦 刘桂莲 王瑛[1] ZHANG Rugang;YIN Yue;LI Daiyun;DUAN Mengqi;LIU Guilian;WANG Ying(Department of Respiratory Medicine,the 960th Hospital of the PLA Joint Logistics Support Force,Jinan 250022,Shandong,China;Chinese PLA Medical School,Beijing 100853,China)

机构地区：[1]中国人民解放军联勤保障部队第960医院呼吸内科,山东济南250022 [2]中国人民解放军总医院研究生院,北京100853

出　　处：《山东大学学报(医学版)》2025年第3期71-75,84,共6页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生科技项目(20230321681)。

摘　　要：目的探讨支原体感染对成人肺功能及呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)的影响。方法选取成人支原体感染患者94例,依据肺部影像学检查分为急性气管-支气管炎组(支气管炎组)52例、肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)组42例,并随机选取同时期健康体检人群50位作为对照组。比较3组人群肺功能及FeNO的差异。结果相较于对照组,支气管炎组与MPP组的肺功能均出现不同程度的下降,3组人群的肺功能差异有统计学意义(P<0.05),而FeNO差异无统计学意义(P>0.05);其中,MPP组与对照组在用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))、一秒率(FEV_(1)/FVC)、呼气峰值流量(peak expiratory flow,PEF)、最大呼气中段流量(maximal mid-expiratory flow curve,MMEF)及上述各值占预计值的百分比(%pred)差异有统计学意义(P<0.017),支气管炎组与对照组在FEV_(1)、FEV_(1)/FVC、PEF、MMEF及上述各值占预计值的百分比差异有统计学意义(P<0.017),MPP组与支气管炎组仅在FVC%pred、FEV_(1)%pred及MMEF%pred的差异有统计学意义(P<0.017)。结论支原体感染患者的肺功能均下降,大、小气道均受损,以阻塞性通气功能障碍为主;MPP患者肺功能下降更为显著,小气道受损更为明显;3组人群FeNO无明显差异。Objective To investigate the effects of Mycoplasma infection on pulmonary function and fractional exhaled nitric oxide(FeNO)production in adults.Methods Based on the results of pulmonary imaging examination,a total of 94 adult patients with Mycoplasma infection were enrolled,in which 52 patients suffered from acute trachea-bronchitis(bronchitis group)and 42 patients suffered from Mycoplasma pneumoniae pneumonia(MPP group).Fifty healthy individuals who underwent physical examination during the same period were selected as a control group.The differences in pulmonary function and FeNO among the three groups were compared.Results The differences in lung function among the three groups were statistically significant(P<0.05).However,there was no statistically significant difference in FeNO among the three groups(P>0.05).Specifically,the MPP group and the control group showed statistically significant differences in forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),FEV_(1)/FVC,peak expiratory flow(PEF),maximal mid-expiratory flow curve(MMEF),and the percentage of each value relative to the predicted value(%pred)(all P<0.017).The bronchitis group and the control group showed statistically significant differences in FEV_(1),FEV_(1)/FVC,PEF,MMEF,and the percentage of each value relative to the predicted value(all P<0.017).The MPP group and the bronchitis group showed statistically significant differences only in FVC%pred,FEV_(1)%pred,and MMEF%pred(all P<0.017).Conclusion All patients with Mycoplasma infection have declined lung function,with damage to both large and small airways,and predominantly obstructive ventilation function impairment.Patients with MPP have even more significant decreases in lung function,with more pronounced damage to the small airways.There is no significant difference in FeNO among the three groups.

关 键 词：支原体 肺炎支原体肺炎 C-反应蛋白 肺功能 呼出气一氧化氮 

分 类 号：R563.1[医药卫生—呼吸系统]