干血斑技术在毒物分析领域的应用与展望  

Research on the Application and Prospects of Dried Blood Spot Technique in Toxicant Analysis

作　　者：苏东斌 董林沛 张云峰 赵鹏 李开开[1] SU Dongbin;DONG Linpei;ZHANG Yunfeng;ZHAO Peng;LI Kaikai(College of Investigation,People’s Public Security University of China,Beijing 100038,China;Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China)

机构地区：[1]中国人民公安大学侦查学院,北京100038 [2]公安部鉴定中心,北京100038

出　　处：《刑事技术》2025年第2期189-196,共8页Forensic Science and Technology

基　　金：公安部技术研究计划(2022JSYJC008)。

摘　　要：干血斑广泛应用于新生儿筛查、临床药物开发、治疗药物监测等场景和相关研究中。近年来,因其采样便捷性、保存稳定性和转运安全性上的显著优势,干血斑样本逐渐引起法庭科学毒物分析领域的重视。本文概述了干血斑技术在毒物分析领域的多个实战场景以及新兴的干血斑分析技术,展现了其广阔应用前景。同时总结了法庭科学毒物分析领域中仍待解决的干血斑应用挑战,为下一步的研究方向提出意见。Dried blood spot(DBS)is a sampling technique in which a small volume of blood is collected on a specifi c type of fi lter paper.Since the 1960s,DBS has been primarily used for the newborn screening of metabolic diseases.With the development of highly sensitive analytical instruments,the dried blood spot technique allows for accurate quantifi cation of ethanol,stimulants,drugs of abuse and heavy metal elements in biological samples.Due to its obvious advantages,the application of DBS in forensic toxicology has witnessed significant growth in the past decade,which is highlighted and presented in this article.Some challenges and suggestions of dried blood spot applications were summarized for the further research as well.

关 键 词：法医毒物学 干血斑技术 毒物分析 采样技术 进展 

分 类 号：DF795.1[医药卫生—法医学]