Harnessing metabolomics for enhanced crop drought tolerance  

作　　者：Ali Raza Muhammad Anas Savita Bhardwaj Rakeeb Ahmad Mir Sidra Charagh Minhas Elahi Xinyue Zhang Reyazul Rouf Mir Wolfram Weckwerth Alisdair R.Fernie Kadambot H.M.Siddique Zhangli Hu Rajeev K.Varshney 

机构地区：[1]Guangdong Key Laboratory of Plant Epigenetics,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518060,Guangdong,China [2]Shenzhen Engineering Laboratory for Marine Algal Biotechnology,Guangdong Technology Research Center for Marine Algal Biotechnology,Longhua Innovation Institute for Biotechnology,College of Life Sciences and Oceanography,Shenzhen University,Shenzhen 518060,Guangdong,China [3]Department of Plant Sciences,Faculty of Biological Sciences,Quaid-i-Azam University,Islamabad 45320,Pakistan [4]Department of Botany,MCM DAV College,Kangra,Himachal Pradesh 176001,India [5]Department of Biotechnology,School of Life Sciences,Central University of Kashmir,Jammu and Kashmir,Ganderbal J&K-191201,India [6]State Key Laboratory of Rice Biology China,National Rice Research Institute,Chinese Academy of Agricultural Sciences,Hangzhou 311401,Zhejiang,China [7]WA State Agricultural Biotechnology Centre,Centre for Crop and Food Innovation,Food Futures Institute,Murdoch University,Murdoch,WA 6150,Australia [8]Molecular Systems Biology Lab(MOSYS),Department of Functional and Evolutionary Ecology,University of Vienna,Vienna 1010,Austria [9]Vienna Metabolomics Center(VIME),University of Vienna,Vienna 1010,Austria [10]Max-Planck-Institute of Molecular Plant Physiology,Potsdam-Golm 14476,Germany [11]The UWA Institute of Agriculture,The University of Western Australia,Crawley,Perth 6009,Australia

出　　处：《The Crop Journal》2025年第2期311-327,共17页作物学报(英文版)

基　　金：supported by Chinese National Key R&DProject for Synthetic Biology(2018YFA0902500);National Natural Science Foundation of China(32273118);The Guangdong Key R&D Project(2022B1111070005);Shenzhen Special Fund for Sustainable Development(KCXFZ20211020164013021);Shenzhen University 2035 Program for Excellent Research(2022B010);supported by a startup grant from the Food Futures Institute of Murdoch University,Australia.

摘　　要：Global crop productivity faces a significant threat from climate change-induced drought stress(DS),which is vital for sustainable agriculture and global food security.Uncovering DS adaptation and tolerance mechanisms in crops is necessary to alleviate climate challenges.Innovative plant breeding demands revolutionary approaches to develop stress-smart plants.Metabolomics,a promising field in plant breeding,offers a predictive tool to identify metabolic markers associated with plant performance under DS,enabling accelerated crop improvement.Central to DS adaptation is metabolomics-driven metabolic regulation,which is critical for maintaining cell osmotic potential in crops.Recent innovations allow rapid mapping of specific metabolites to their genetic pathways,providing a valuable resource for plant scientists.Metabolomics-driven molecular breeding,integrating techniques such as mQTL and mGWAS,enhances our ability to discover key genetic elements linked to stress-responsive metabolites.This integration offers a beneficial platform for plant scientists,yielding significant insights into the complex metabolic networks underlying DS tolerance.Therefore,this review discusses(1)insights into metabolic regulation for DS adaptation,(2)the multifaceted role of metabolites in DS tolerance and nutritional/yield trait improvement,(3)the potential of single-cell metabolomics and imaging,(4)metabolomics-driven molecular breeding,and(5)the application of metabolic and genetic engineering for DS-tolerant crops.We finally propose that the metabolomics-driven approach positions drought-smart crops as key contributors to future food production,supporting the vital goal of achieving“zero hunger”.

关 键 词：Amino acids Climate change Food security mQTL and mGWAS Metabolic engineering Single-cell metabolomics Water scarcity 

分 类 号：S311[农业科学—作物栽培与耕作技术]