透明质酸治疗骨关节炎的研究进展  

Progress on hyaluronic acid in treatment of osteoarthritis

作　　者：韩文英 阮海华[1] HAN Wenying;RUAN Haihua(School of Biotechnology and Food Science,Tianjin University of Commerce,Beichen 300134,China)

机构地区：[1]天津商业大学生物技术与食品科学学院,北辰300134

出　　处：《生物学杂志》2025年第2期99-106,共8页Journal of Biology

基　　金：国家自然科学基金面上项目(31870122);天津市自然科学基金项目(18JCYBJC96000)。

摘　　要：系统介绍不同分子量的透明质酸对炎症通路的影响,以及透明质酸与不同受体特异性结合后的细胞活动。回顾不同分子量的透明质酸治疗骨关节炎的机制研究及其临床研究,主要分析透明质酸在治疗骨关节炎中维持关节内理化性质、调节炎症信号通路和保护关节软骨等作用,并指出关节内注射透明质酸治疗骨关节炎的不足。从治疗骨关节炎的角度介绍透明质酸的抗炎作用、促炎作用和软骨保护作用,以期为透明质酸治疗骨关节炎的相关研究提供参考。The effects of hyaluronic acid of different molecular weights on inflammatory pathways and the cellular activities of hyaluronic acid after specific binding to different receptors were systematically described.Mechanistic studies of hyaluronic acid of different molecular weights in the treatment of osteoarthritis and its clinical studies were also reviewed,mainly analyzing the role of hyaluronic acid in the treatment of osteoarthritis in maintaining intra-articular physicochemical properties,regulating inflammatory signaling pathways and protecting articular cartilage,and pointing out the shortcomings of intra-articular injection of hyaluronic acid in the treatment of osteoarthritis.This paper introduced the anti-inflammatory,pro-inflammatory and cartilage-protective effects of hyaluronic acid from the perspective of the treatment of osteoarthritis,with a view to providing a reference for the relevant research on hyaluronic acid treatment of osteoarthritis.

关 键 词：透明质酸 骨关节炎 抗炎 免疫调节 软骨保护 

分 类 号：Q538[生物学—生物化学]