DPM1基因单核苷酸多态性与儿童过敏性紫癜的相关性  

Association between DPM1 gene single nucleotide polymorphism and Henoch-Sch nlein purpura in children

作　　者：高鑫[1] 张秋业[1] 常红[1] 柏翠[1] 王大海 邵乐平 林毅[1] GAO Xin;ZHANG Qiuye;CHANG Hong;BAI Cui;WANG Dahai;SHAO Leping;LIN Yi(Department of Nephrology,Rheumatology and Immunology,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院儿童肾脏风湿免疫科,山东青岛266003 [2]青岛市市立医院肾内科

出　　处：《精准医学杂志》2025年第1期55-59,共5页Journal of Precision Medicine

基　　金：国家自然科学基金项目(82170717)。

摘　　要：目的探讨DPM1基因单核苷酸多态性与儿童过敏性紫癜的相关性。方法选择2021年4月—2022年3月于青岛大学附属医院接受诊治的过敏性紫癜儿童156例作为病例组,另外选择同期体检健康的儿童152例作为对照组。根据患儿是否出现腹痛和关节疼痛的症状分为有腹痛亚组、无腹痛亚组和有关节痛亚组、无关节痛亚组;按照患儿是否伴有紫癜性肾炎将其分为紫癜性肾炎亚组与非紫癜性肾炎亚组。收集各组临床资料,并从受试者外周血中提取全血DNA,使用iMLDR^(TM)多重SNP分型技术对DPM1基因的rs73909842位点进行基因型鉴定和统计学分析。结果病例组rs73909842基因型C/G、G/G、C/C频率与对照组相比,差异具有统计学意义(χ^(2)=7.548,OR=2.593,95%CI=1.292~5.208,P<0.05);等位基因C频率与对照组比较,差异有统计学意义(χ^(2)=6.053,OR=2.245,95%CI=1.162~4.337,P<0.05)。rs73909842基因型及等位基因频率在各临床亚组中差异无统计学意义。结论DPM1基因rs73909842位点的SNP多态性与儿童过敏性紫癜的发病相关,等位基因C可能是其易感基因。Objective To investigate the association between DPM1 gene single nucleotide polymorphism and Henoch-Sch nlein purpura in children.Methods A total of 156 children with Henoch-Sch nlein purpura who were diagnosed and treated in The Affiliated Hospital of Qingdao University from April 2021 to March 2022 were enrolled as case group,and 152 healthy children who underwent physical examination during the same period of time were enrolled as control group.According to the presence or absence of the symptoms of abdominal pain and joint pain,the children were divided into abdominal pain group,non-abdominal pain group,joint pain group,and non-joint pain group;according to whether a child was comorbid with purpura nephritis,they were divided into purpura nephritis group and non-purpura nephritis group.Related clinical data were collected from each group;whole blood DNA was extracted from the peripheral blood of subjects,and the iMLDR^(TM) multiplex SNP typing technique was used to determine the genotype of the rs73909842 locus of the DPM1;a statistical analysis was performed.Results There were significant differences in the frequency of C/G,G/G,and C/C genotypes at the rs73909842 locus between the case group and the control group(χ^(2)=7.548,OR=2.593,95%CI=1.292-5.208,P<0.05),and there was also a significant difference in the frequency of C allele between the two groups(χ^(2)=6.053,OR=2.245,95%CI=1.162-4.337,P<0.05).There were no significant diffe-rences in the frequencies of genotypes and alleles at the rs73909842 locus between the above clinical subgroups.Conclusion The single nucleotide polymorphism of the DPM1 gene at the rs73909842 locus was associated with the onset of Henoch-Sch nlein purpura in children,and allele C may be a susceptible gene.

关 键 词：IgA血管炎 甘露糖基转移酶类 多态性 单核苷酸 基因型 等位基因 基因频率 儿童 

分 类 号：R725.546[医药卫生—儿科]