孕中期维生素D缺乏现状及相关影响因素研究  

To study the status of vitamin D deficiency and related influencing factors in the second trimester of pregnancy

作　　者：蔡昭美 Cai Zhaomei(Affiliated Hospital of Beihai Health School,Beihai Guangri,536100,China)

机构地区：[1]广西北海市卫生学校附属医院,广西北海536100

出　　处：《中国产前诊断杂志(电子版)》2025年第1期18-23,共6页Chinese Journal of Prenatal Diagnosis(Electronic Version)

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2021LGX001)。

摘　　要：目的分析孕中期孕妇维生素D缺乏现状,并对相关影响因素进行探讨。方法选取105例孕中期孕妇,均于2022年1月至2024年1月在广西北海市卫生学校附属医院接受定期产检,选择液相色谱-串联质谱法对孕中期孕妇的血清25-羟维生素D(25-OH-D)水平进行测定;按照测定结果将全部孕中期孕妇分为缺乏组(25-OH-D<20μg/L)与正常组(25-OH-D≥20μg/L);对两组的一般资料进行收集,并对其近3个月的生活方式进行了解,分析维生素D缺乏现状,并制定有效的防治对策。结果105例孕中期孕妇的血清25-OH-D水平检测结果为(21.48±2.36)μg/L;其中26例孕中期孕妇维生素D充足,31例孕中期孕妇维生素D不足,两者均纳入到正常组;另外48例孕中期孕妇维生素D缺乏,纳入到缺乏组,其中6例孕中期孕妇维生素D严重缺乏。单因素分析结果发现,缺乏组、正常组的季节、使用防晒霜、喜好阳光、户外运动、维生素补充剂应用等情况比较差异有统计学意义(P<0.05);而在年龄、胎次、孕前体质量指数、文化程度、居住地以及维生素D丰富食物食用等情况比较差异无统计学意义(P>0.05)。将单因素分析中比较差异有统计学意义的因素进行多因素分析;Logistic多因素回归分析结果发现,孕中期维生素D缺乏的独立影响因素包括了喜好阳光、户外活动、维生素D补充剂以及季节(P<0.05)。结论维生素D缺乏在孕中期孕妇中较为常见,而孕中期孕妇维生素D缺乏的独立影响因素包括了喜好阳光、户外活动、维生素D补充剂以及季节,应针对相关影响因素制定有针对性的防治对策,以有效改善维生素D缺乏现象。Objective To analyze the status of vitamin D deficiency in pregnant women in the second trimester and explore the related influencing factors.Methods A total of 105 pregnant women in the second trimester of pregnancy were selected and received regular prenatal examination in the Affiliated Hospital of Beihai Health School of Guangxi from January 2022 to January 2024.Liquid chromatography-tandem mass spectrometry was used to determine the serum 25-hydroxyvitamin D(25-OH-D)level of pregnant women in the second trimester of pregnancy.All pregnant women were divided into deficiency group(25-OH-D<20μg/L)and normal group(25-OH-D≥20μg/L).The general information of the two groups was collected,and the lifestyle of the two groups in the past 3 months was understood,the status of vitamin D deficiency was analyzed,and effective prevention and treatment strategies were formulated.Results The serum 25-OH-D level of 105 women in the second trimester of pregnancy was(21.48±2.36)μg/L.Among them,26 pregnant women in the second trimester had adequate vitamin D,31 pregnant women in the second trimester had insufficient vitamin D,both of which were included in the normal group;Another 48 pregnant women with vitamin D deficiency in the second trimester were included in the deficiency group,of which 6 were severely deficient in the second trimester.The results of univariate analysis showed that there were statistically significant differences in season,sunscreen use,sun preference,outdoor exercise and vitamin supplement application between the deficiency group and the normal group(P<0.05).There was no significant difference in age,parity,pre-pregnancy body mass index,education level,place of residence and vitamin D-rich food consumption(P>0.05).Multivariate analysis was carried out for the factors with statistical significance in the single factor analysis.Logistic multivariate regression analysis showed that the independent influencing factors of vitamin D deficiency in the second trimester included sunshine preference,outdoor

关 键 词：孕中期 25-羟维生素D 维生素D缺乏 多因素分析 

分 类 号：R715[医药卫生—妇产科学]