从肠黏膜屏障的角度探讨玉屏风散干预慢性阻塞性肺疾病的机制  

Exploring the mechanism of Yu Pingfeng Powder in the treatment of chronic obstructive pulmonary disease from the perspective of the intestinal mucosal barrier

作　　者：杨建波 夏洪涛[2] 王衍华[2] YANG Jianbo;XIA Hongtao;WANG Yanhua(School of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430065,Hubei,China;Department of Traditional Chinese Medicine,Shenzhen Luohu People's Hospital,Shenzhen 518000,Guangdong,China)

机构地区：[1]湖北中医药大学中医学院,湖北武汉430065 [2]深圳市罗湖区人民医院中医内科,广东深圳518000

出　　处：《广州医科大学学报》2025年第1期15-19,共5页Academic Journal of Guangzhou Medical University

基　　金：广东省中医药局科研项目(20221345)。

摘　　要：目的:探讨玉屏风散在慢性阻塞性肺疾病(COPD)治疗中的作用及其机制。方法:选取2023年2月至2024年7月深圳市罗湖区人民医院就诊的60例门诊或住院的COPD患者,随机分为对照组和观察组,每组30例,对照组接受西医常规治疗,观察组在西医常规治疗基础上加用玉屏风颗粒。对比两组治疗前后的临床症状改善情况、肺功能指标、血清中的DAO、D-乳酸、LPS、Occludin和ZO-1水平以及肠道菌群结构的变化,评估玉屏风颗粒的疗效和安全性。结果:玉屏风颗粒能够显著改善COPD患者的临床症状和肺功能(均P<0.05),降低血清中的DAO、D-乳酸、LPS、Occludin和ZO-1水平(治疗前11.79±3.20 ng/mL,15.56±6.08μg/mL,15.45±1.85ng/mL,4.15±1.11 ng/mL,2.55±1.77 ng/mL,治疗后10.09±2.87 ng/mL,13.40±6.11μg/mL,15.15±1.86 ng/ml,3.75±0.71 ng/mL,2.20±1.47 ng/mL,均P<0.05)。结论:玉屏风能改善COPD患者肺功能,调节肠道菌群结构,改善肠黏膜屏障功能,且药物安全性良好,值得推广应用。Objective:To explore the role and mechanism of Yu Pingfeng Powder in the treatment of Chronic Obstructive Pulmonary Disease(COPD).Methods:A total of 60 outpatients or inpatients with COPD who visited the People′s Hospital of Luohu District,Shenzhen,from February 2023 to July 2024 were randomly divided into a control group and an observation group,with 30 cases in each group.The control group received conventional Western medicine treatment,while the observation group received Yu Pingfeng Granules in addition to the conventional Western medicine treatment.The clinical symptom improvement,pulmonary function indicators,levels of DAO,D-lactate,LPS,Occludin,and ZO-1 in serum,and changes in gut microbiota structure were compared between the two groups before and after treatment to evaluate the efficacy and safety of Yu PingfengGranules.Results:Yu Pingfeng Granules significantly improved the clinical symptoms and pulmonary function of COPD patients(all P<0.05),reduced the levels of DAO,D-lactate,LPS,Occludin,and ZO-1 in serum(pre-treatment levels of DAO,D-lactate,Occludin,ZO-1,and LPS were 11.79±3.20 ng/mL,15.56±6.08μg/mL,4.15±1.11 ng/mL,2.55±1.77 ng/mL,and 15.45±1.85 ng/mL,respectively,and post-treatment levels were 10.09±2.87 ng/mL,13.40±6.11μg/mL,3.75±0.71 ng/mL,2.20±1.47 ng/mL,and 15.15±1.86 ng/mL,respectively,all P<0.05).Conclusion:Yu Pingfeng can improve pulmonary function in COPD patients,regulate gut microbiota structure,and enhance intestinal mucosal barrier function,with good drug safety.It is worthy of promotion and application.

关 键 词：慢性阻塞性肺疾病 玉屏风散 肠黏膜屏障 肠道菌群 临床疗效 

分 类 号：R256.12[医药卫生—中医内科学]