血清IGF-1联合肺部超声对早产儿支气管肺发育不良的早期预测研究  

Early prediction of bronchopulmonary dysplasia in premature infants by serum IGF-1 combined with pulmonary ultrasound

作　　者：瞿色华 陈爽 陈云 周梦竹 张阵 陈信 QU Sehua;CHEN Shuang;CHEN Yun;ZHOU Mengzhu;ZHANG Zhen;CHEN Xin(Department of Pediatrics,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233003,Anhui,China)

机构地区：[1]蚌埠医科大学第一附属医院儿科,安徽蚌埠233003

出　　处：《广州医科大学学报》2025年第1期25-29,共5页Academic Journal of Guangzhou Medical University

基　　金：蚌埠医科大学自然重点项目(2022byzd043);蚌埠医科大学临床研究专项(2022byflc009)。

摘　　要：目的:探究血清胰岛素样生长因子-1(IGF-1)联合肺部超声对早产儿支气管肺发育不良的早期诊断价值。方法:选取我院2020年1月1日至2023年12月31日符合条件的80例早产儿为研究对象,以其中40例支气管肺发育不良早期患儿为研究组,40例健康新生儿为对照组,对两组患儿进行血清IGF-1检测与肺部超声检查,评估患者血清IGF-1水平、肺部超声检查结果。结果:出生后1 d、出生后7 d、出生后14 d两组患儿血清IGF-1水平差异显著,且研究组显著低于对照组(P<0.05);出生3 d时超声检查显示研究组患儿全部患有肺泡间质综合征,而对照组患儿52.50%患有肺泡间质综合征,两组轻度肺泡间质综合征发生情况无明显差异(P>0.05),研究组肺泡间质综合征中度、重度发生率及总发生率均显著高于对照组(P<0.05);出生12 d时超声检查显示研究组患儿仍全部患有肺泡间质综合征,同时发生胸膜线改变;82.5%发生肺实变或碎片征,10%发生胸腔积液;而对照组患儿仅10%仍患有肺泡间质综合征,6%发生胸膜线改变,12.5%发生肺实变或碎片征,2.5%发生胸腔积液;两组胸腔积液发生情况无明显差异(P>0.05),研究组肺泡间质综合征、胸膜线改变、肺实变或碎片征发生率高于对照组(P<0.05)。血清IGF-1、肺部超声联合AUC高于血清IGF-1、肺部超声单项检测(Z=4.753,13.784,P<0.05)。结论:血清IGF-1联合肺部超声对早产儿支气管肺发育不良的早期预测效果较好。Objective:To investigate the value of serum IGF-1 combined with pulmonary ultrasound in early diagnosis of bronchopulmonary dysplasia in premature infants.Methods:A total of 80 eligible premature infants in our hospital from January 1,2020 to December 31,2023 were selected as the study objects,40 children with early bronchopulmonary dysplasia were selected as the study group and 40 healthy newborns were selected as the control group.Serum IGF-1 detection and lung ultrasound examination were performed on the two groups of children.Serum IGF-1 level and pulmonary ultrasonography were evaluated.Results:There were significant differences in serum IGF-1 level between the two groups 1 d,7 d and 14 d after birth,and the serum level in the study group was significantly higher than that in the control group(P<0.05).Ultrasound examination at 3 d birth showed that all the children in the study group had alveolar interstitial syndrome,while 52.50%of the children in the control group had alveolar interstitial syndrome.There was no significant difference in the occurrence of mild alveolar interstitial syndrome between the two groups(P>0.05).The incidence of moderate,severe and total incidence of alveolar interstitial syndrome in the study group was significantly higher than that in the control group(P<0.05).At 12 days after birth,ultrasound examination showed that all the children in the study group still suffered from alveolar interstitial syndrome with changes in the pleural line.82.5%had lung consolidation or fragmentation,10%had pleural effusion.In the control group,only 10%of children still had alveolar interstitial syndrome,6%had pleural line changes,12.5%had lung consolidation or fragmentation,and 2.5%had pleural effusion.There was no significant difference in the occurrence of pleural effusion between the two groups(P>0.05).The incidence of alveolar interstitial syndrome,pleural line change,lung consolidation or fragmentation in the study group was higher than that in the control group(P<0.05).The combined AUC of serum

关 键 词：血清IGF-1 肺部超声 早产儿 支气管肺发育不良 早期预测 

分 类 号：R445.1[医药卫生—影像医学与核医学]