高同型半胱氨酸血症的研究现状及进展  

Research Status and Progress of Hyperhomocysteinemia

作　　者：孙可歆 林凡琪 王淑美 张译文 李浩瑞 李明光 SUN Kexin;LIN Fanqi;WANG Shumei;ZHANG Yiwen;LI Haorui;LI Mingguang(College of Laboratory Medicine,Jilin Medical University,Jilin City,Jilin Province 132013,China)

机构地区：[1]吉林医药学院检验学院,吉林吉林132013

出　　处：《吉林医药学院学报》2025年第2期135-139,共5页Journal of Jilin Medical University

基　　金：吉林省教育厅科学技术研究规划项目(JJKH20220463KJ,JJKH20220472KJ);吉林省大学生创新创业训练计划项目(202213706006)。

摘　　要：高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)是一种氨基酸代谢病,其核心特征是血液同型半胱氨酸(ho⁃mocysteine,Hcy)水平的异常升高,这是由于Hcy向蛋氨酸的转化受阻所致。研究表明,HHcy不仅是动脉粥样硬化的重要诱因,也是脑卒中发病的独立风险因素,对人体健康构成了严重的威胁。本文将围绕HHcy与其相关疾病之间的作用机制进行探讨,旨在为临床提供全新视角,以便为更好地预防、诊断和治疗HHcy提供新思路。Hyperhomocysteinemia(HHcy)is an amino acid metabolic disorder characterized by abnormally elevated levels of homocysteine(Hcy)in the blood,resulting from the impaired conversion of Hcy to methionine.Studies have shown that HHcy is not only a significant risk factor for atherosclerosis but also an independent risk factor for stroke,posing a serious threat to human health.This paper will explore the mechanisms by which HHcy is associated with various diseases,aiming to provide a new perspective for the clinic,in order to offer new ideas for better prevention,diagnosis,and treatment of HHcy.

关 键 词：同型半胱氨酸 高同型半胱氨酸血症 心血管病 慢性肾病 糖尿病 H型高血压 

分 类 号：R589[医药卫生—内分泌]