褪黑素对生殖细胞的发育调控和在辅助生殖技术领域的应用  

Regulation of Reproductive Cell Development and Application of Melatonin in Assisted Reproductive Technology

作　　者：何佳琪 杨佳鑫 陈素君 冯嘉嘉 潘晓燕[1] HE Jiaqi;YANG Jiaxin;CHEN Sujun;FENG Jiajia;PAN Xiaoyan(Center for Reproductive Medicine,Jilin Medical University,Jilin City,Jilin Province 132013,China)

机构地区：[1]吉林医药学院生殖医学研究中心,吉林吉林132013

出　　处：《吉林医药学院学报》2025年第2期140-143,153,共5页Journal of Jilin Medical University

基　　金：吉林省自然科学基金项目(YDZJ202301ZYTS125);大学生创新创业训练项目(S202213706031)。

摘　　要：氧化应激损伤是影响生殖细胞体内和体外发育的主要因素。为解决这一问题,人们将抗氧化剂应用于生殖细胞的发育过程中。松果体分泌的褪黑素因其强大的抗氧化特性及其在生殖细胞发育中的作用而逐渐引起关注,其可清除过量氧自由基,保护DNA和质膜的完整性,提高生殖细胞的发育能力,被认为是一种很有前途的生殖疾病治疗激素。本文将对褪黑素的特性、褪黑素在生殖细胞发育中的作用和在辅助生殖技术中的应用展开论述,以期促进其在生殖领域的应用,提高生育成功率。Oxidative stress is the primary factor influencing germ cell development both in vitro and in vivo.In order to address this issue,antioxidants have been employed for promoting germ cell development.Melatonin,a hormone secreted by the pineal gland,has garnered increasing attention due to its potent antioxidant properties and its role in enhancing germ cell development.It effectively eliminates excessive oxygen free radicals,safeguards DNA and plasma membrane integrity,enhances the developmental capacity of germ cells,and is regarded as a promising therapeutic agent for reproductive disorders.This paper aims to explore the characteristics of melatonin,the role of melatonin in germ cell development and its application in assisted reproductive technology,with an ultimate goal of advancing its utilization within the field of reproduction and improving fertility success rates.

关 键 词：褪黑素 生殖细胞 氧化应激 辅助生殖 

分 类 号：R321.1[医药卫生—人体解剖和组织胚胎学]