结石通联合坦索罗辛对肾结石输尿管软镜碎石术后清石率的影响  

The Effect of Jieshitong Combined with Tamsulosin on the Stone Clearance Rate after Ureteroscopic Lithotripsy for Renal Calculi

作　　者：叶韬[1] 高加胜[1] 张海峰 刘启航 张文圣[1] YE Tao;GAO Jiasheng;ZHANG Haifeng;LIU Qihang;ZHANG Wensheng(The First People's Hospital of Jiujiang,Jiujiang 332000,China)

机构地区：[1]九江市第一人民医院,江西九江332000

出　　处：《江西中医药大学学报》2025年第2期45-48,共4页Journal of Jiangxi University of Chinese Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0429)。

摘　　要：目的:探究结石通胶囊联合盐酸坦索罗辛缓释胶囊对肾结石输尿管软镜碎石术(RIRS)术后清石率的影响。方法:选取2022年1月—2023年8月在九江市第一人民医院接受RIRS治疗的肾结石患者80例,按随机数字表法分为对照组(40例)和观察组(40例),对照组予盐酸坦索罗辛缓释胶囊治疗,观察组予结石通胶囊联合盐酸坦索罗辛缓释胶囊治疗。比较2组结石清除率、结石清除时间、肾功能指标、肾绞痛与尿路感染发生率及不良反应等。结果:观察组RIRS术后2、4、12周结石清除率均高于对照组,首次排出结石与结石排净时间均短于对照组,差异均有统计学意义(P<0.05);观察组治疗4周血肌酐(Scr)、β微球蛋白(β2-MG)、胱抑素C(Cys-C)水平均低于对照组,差异有统计学意义(P<0.05);观察组肾绞痛与尿路感染发生率均低于对照组,差异有统计学意义(P<0.05);2组不良反应比较差异无统计学意义(P>0.05)。结论:肾结石患者RIRS术后采用结石通胶囊联合盐酸坦索罗辛缓释胶囊治疗可提高结石清除率、缩短排石时间,且可减轻肾功能损伤、降低肾绞痛与尿路感染发生率,安全性较好。Objective:To investigate the effect of Jieshitong Capsules combined with sustained-release capsules of tamsulosin hydrochloride on the postoperative stone clearance rate of renal calculi undergoing ureteroscopic lithotripsy(RIRS).Methods:80 patients with kidney stones who received RIRS treatment at the First People's Hospital of Jiujiang City from January 2022 to August 2023 were selected and randomly divided into a control group(40 cases)and an observation group(40 cases)using a random number table.The control group was treated with sustained-release capsules of tamsulosin hydrochloride,while the observation group was treated with a combination of Shishitong capsules and tamsulosin hydrochloride sustained-release capsules.Compare the stone clearance rate,stone clearance time,renal function indicators,incidence of renal colic and urinary tract infection,and adverse reactions between two groups.Results:The stone clearance rate of the observation group was higher than that of the control group at 2,4,and 12 weeks after RIRS surgery.The time for first stone expulsion and stone clearance were shorter than those of the control group,and the differences were statistically significant(P<0.05);The serum creatinine(Scr),β-microglobulin(β2-MG),and cystatin C(Cys-C)in the observation group were all lower than those in the control group after 4 weeks of treatment,and the differences were statistically significant(P<0.05);The incidence of renal colic and urinary tract infection in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:The use of Shishitong capsules combined with sustained-release hydrochloric acid tamsulosin capsules for the treatment of renal stone patients after RIRS surgery can improve stone clearance rate,shorten stone clearance time,reduce renal function damage,lower the incidence of renal colic and urinary tract infection,and

关 键 词：肾结石 输尿管软镜碎石术 结石通胶囊 盐酸坦索罗辛缓释胶囊 结石清除率 

分 类 号：R256.52[医药卫生—中医内科学]