全球类器官科学研究竞争与合作态势分析  

Analysis of competition and collaboration of global organoid research

作　　者：陈娟[1] 龙俊羽 李卓婷[3] 潘黎姿 欧阳昭连[1] CHEN Juan;LONG Jun-yu;LI Zhuo-ting;PAN Li-zi;OUYANG Zhao-lian(Institute of Medical Information&Library,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100020,China;School of Medical Humanity,Peking University Health Science Center,Beijing 100191,China;Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院医学信息研究所,北京100020 [2]北京大学医学部医学人文学院,北京100191 [3]中国医学科学院北京协和医院,北京100730

出　　处：《中国新药杂志》2025年第7期673-683,共11页Chinese Journal of New Drugs

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-056);国家自然科学基金资助项目(L1924064);深圳市卫生健康发展研究和数据管理中心:组织工程与再生医学专题报告项目(sz20240119);深圳市卫生健康发展研究和数据管理中心:类器官全球研发与临床转化态势研究(SZ20240368)。

摘　　要：目的:分析全球类器官领域的科研竞争与合作态势。方法:2024年1月,在Web of Science中检索类器官相关论文,通过共被引分析、文献计量学分析和社会网络分析识别研究热点以及领先国家、机构和研究者。结果:1990年至今,全球类器官领域科技论文共计10477篇,其中2018年至今占82.4%,研究集中在肿瘤、肝肾、肠道上皮、人脑和视网膜等类器官的构建。美国发文最多(4632篇),且合作对象数量(75个)和次数(3405次)也最多。中国发文量居第2位(1970篇),但合作对象数量(54个)和次数(1194次)远少于美国。机构层面,哈佛大学的发文量(534篇)、合作对象数量(347个)和次数(1495次)均领先,来自美国之外的中国科学院、荷兰乌特勒支大学、英国剑桥大学、德国癌症研究中心等也有较高的合作排名。荷兰Hans Clevers教授发文最多,我国秦建华团队和华国强团队发文较多。结论:类器官领域在过去10年间快速发展,众多研究集中在肿瘤、肝脏、肠道、脑和视网膜等类器官的构建。美国绝对领先,中国也是国际合作的重要参与者。哈佛大学实力突出,是全球合作中心,来自中国、荷兰、英国、德国的个别机构则是各自区域的中心。Objective:To analyze the global research competition and collaboration landscape in the field of organoids.Methods:In January 2024,papers related to organoids were retrieved from database of Web of Science.Through co-citation analysis,bibliometric analysis,and social network analysis,research hotspots,leading countries,institutions,and researchers were identified.Results:Since 1990,a total of 10477 scientific papers have been published globally in the field of organoids,with 82.4%published since 2018.Researches have primarily focused on the construction of organoids related to tumors,liver and kidney,intestinal epithelium,human brain,and retina.The United States leads both the publications(4632 papers)and collaboration partners(75),as well as instances(3405).China ranks second in terms of publications(1970 papers);however,its number of collaboration partners(54)and instances(1194)are far lower than those reported by the United States.At the institutional level,Harvard University leads in terms of publications(534 papers),collaboration partners(347),and instances(1495).Other high-ranking institutions outside the U.S.include the Chinese Academy of Sciences,Utrecht University in the Netherlands,Cambridge University in the UK,and the German Cancer Research Center.Professor Hans Clevers from the Netherlands is noted for having published the highest number of papers,while in China,significant contributions have been made by research teams led by Jianhua Qin and Guoqiang Hua.Conclusion:The field of organoids has experienced rapid development over the past decade,with numerous studies focused on the construction of organoids for various applications,including tumors,liver,intestine,brain,and retina.The U.S.holds a dominant position,while China is an important participant in international collaboration.Harvard University stands out as a global collaboration hub,while institutions from China,the Netherlands,the UK,and Germany serve as regional hubs.

关 键 词：类器官 基础研究 国际合作 科技论文 社会网络分析 文献计量学 

分 类 号：R95[医药卫生—药学]