基于专利引文网络的类器官领域技术主路径分析  

Analysis of the main technological pathways in the organoid field based on patent citation networks

作　　者：张婷[1] 陈娟[1] 卢岩 徐东紫 欧阳昭连[1] ZHANG Ting;CHEN Juan;LU Yan;XU Dong-zi;OUYANG Zhao-lian(Institute of Medical Information/Medical Library,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing 100020,China)

机构地区：[1]中国医学科学院/北京协和医学院医学信息研究所/图书馆,北京100020

出　　处：《中国新药杂志》2025年第7期684-692,共9页Chinese Journal of New Drugs

基　　金：中国医学科学院医学与健康科技创新工程“医学知识管理与智能化知识服务关键技术研究”项目(2021-I2M-1-056)。

摘　　要：目的:基于专利引文网络探索类器官领域的技术发展主路径。方法:本研究通过构建类器官领域的专利引文网络,采用搜索路径连接数算法(search path link count,SPLC)计算遍历权重,对类器官领域开展主路径分析,探索该领域的技术发展轨迹。结果:类器官领域共有专利申请2 250项,包含专利引文12 722件;专利申请数量逐年增长,技术开发聚焦于疾病模型、药物筛选、细胞培养及器官芯片等方向。主路径分析显示,全局主路径上专利数量最多,有12件,包含1条技术路线,全局关键路径主路径与全局主路径一致;局部前向主路径上有10件专利,包含1条技术路线;这2条技术路线反映出中国类器官领域的技术发展轨迹,中国技术创新聚焦于基于肿瘤类器官技术的疾病机制研究、基于肺癌类器官模型的疾病机制研究、肺癌类器官模型的开发与优化。局部后向主路径上有9件专利,包含2条技术路线,局部关键路径主路径与局部后向主路径一致;这2条技术路线反映出美国类器官领域的技术发展轨迹,技术创新聚焦于胃肠道类器官培养与疾病模型研究、干细胞驱动的器官功能修复技术、细胞移植与器官再生。结论:本研究通过类器官领域的专利主路径分析,识别技术发展轨迹,从情报学角度为类器官研发提供信息支撑。Objective:To explore the main paths on technological development in the organoid field based on patent citation networks.Methods:This study constructs a patent citation network for the organoid field and applies the search path link count(SPLC) algorithm to calculate traversal weights for main path analysis,aiming to investigate the technological development trajectory in this area.Results:The organoid field includes 2,250 patent applications and 12,722 patent citations.The number of patent applications has been increasing annually,with the technological developments focused on disease models,drug screening,cell culture and organoid chip.Main path analysis reveals that the most patents,twelve in total,appear on the global main path,which contains one technological route consistent with the global key-route path.While the local forward main path contains ten patents,with one technological route,reflecting China's technological trajectory in organoid development,focusing on disease mechanism research based on tumor organoids,as well as development and optimization of lung cancer organoid models.The local backward main path contains nine patents and two technological routes,reflecting the American trajectory in organoid technology,focusing on gastrointestinal organoid cultivation and disease models,stem cell-driven organ function repair,as well as cell transplantation and organ regeneration.Conclusion:This study identifies technological development trajectories through main path analysis of patents in the organoid field,providing intelligence support for R&D in organoids from a perspective of information science.

关 键 词：类器官 专利引文网络 主路径分析 搜索路径连接数算法 

分 类 号：R95[医药卫生—药学]