器官芯片技术在药动学领域的研究现状及应用前景  

Current research status and future application prospects of organ-on-a-chip technology in pharmacokinetics

作　　者：黎一志 申少磊 王挥豪 王俊龙 刘莉 LI Yi-zhi;SHEN Shao-lei;WANG Hui-hao;WANG Jun-long;LIU Li(Shanghai Biomass Pharmaceutical Product Evaluation Professional Public Service Platform,Center for Pharmacological Evaluation and Research,China State Institute of Pharmaceutical Industry,Shanghai 200437,China;School of Pharmacy,Fudan University,Shanghai 201203,China;China State Institute of Pharmaceutical Industry Clinical Research Center,Shanghai 200437,China)

机构地区：[1]中国医药工业研究总院药理评价研究中心上海市生物物质成药性公共服务平台,上海200437 [2]复旦大学药学院,上海201203 [3]中国医药工业研究总院临床研究中心,上海200437

出　　处：《中国新药杂志》2025年第7期699-705,共7页Chinese Journal of New Drugs

基　　金：先导物成药性研究与药物开发平台建设项目(23002400100)。

摘　　要：准确预测药物的药动学参数对于成功开发新型药物至关重要,传统的药动学研究主要使用动物作为研究对象,但是由于动物与人体在结构和生理学方面存在着种属差异,致使动物实验对人体药动学的参数预测能力达不到预期。近年来,器官芯片的发展显示出巨大的潜力,它通过利用人源细胞构建体外微生理系统,具有再现人体关键生理参数的潜力,为预测人体的药动学和药效学参数提供体外方法。本文系统地介绍了单芯片模型与多芯片模型在药动学领域的研究现状,同时探讨了器官芯片模型向体内转化的可靠性,并对器官芯片存在的挑战及应用前景进行综述。Accurate prediction of pharmacokinetic parameters is crucial for the successful development of novel drugs.Traditional pharmacokinetic studies mainly utilized animals models;however,due to species differences in structure and physiology between animals and humans,the prediction of human pharmacokinetic parameters from animal experiments falls short of expectations.In recent years,the development of organ-on-a-chip(OOC) has shown considerable potential as an in vitro method for predicting pharmacokinetic and pharmacodynamic parameters in humans by constructing in vitro microphysiological systems utilizing human-derived cells.It has the potential to recapitulate key physiological parameters in the human body.This paper systematically introduces the current research status of single-chip models and multichip models in the field of pharmacokinetics,and also discusses the reliability of the translation of OOC models to in vivo circumstance,providing an overview of the both the challenges of organ-on-a-chip and the prospects for their application.

关 键 词：微流控 器官芯片 微生理系统 药动学 药效学 

分 类 号：R91[医药卫生—药学]