基于法尼醇X受体探讨中医药抗胆汁淤积机制研究进展  

Exploring the mechanism of anti-cholestasis of Chinese medicine based on farnesol X receptor

作　　者：唐银佩 朱正望 王琳琳[1] 赵静涵 王兵 朱平生[1] TANG Yin-pei;ZHU Zheng-wang;WANG Lin-lin;ZHAO Jing-han;WANG Bing;ZHU Ping-sheng(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;The Sixth People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200240,China)

机构地区：[1]河南中医药大学,郑州450046 [2]上海交通大学医学院附属第六人民医院,上海200240

出　　处：《中国新药杂志》2025年第7期706-712,共7页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(82074340);河南省“双一流”创建学科中医学科学研究专项资助项目(HSRP-DFCTCM-2023-1-19,HSRP-DFCTCM-2023-8-31,HSRP-DFCTCM-2023-8-32);上海市2023年度“科学与创新行动计划”自然科学基金面上项目(23ZR1448400)。

摘　　要：胆汁淤积是多种急慢性肝病共有的病理状态,主要特征为胆汁酸(bile acids,BAs)等胆汁成分在肝脏和体循环内过度蓄积,临床主要表现为黄疸、疲劳及瘙痒等,病情迁延难愈,若不及时干预,持续胆汁淤积可进一步发展为肝纤维化、肝硬化、肝衰竭甚至终末期肝病。胆汁淤积发病机制复杂,目前缺乏有效的治疗药物。近年研究表明,法尼醇X受体(farnesol X receptor,FXR)通过调控胆汁主要成分BAs的合成、转运、代谢及重吸收,在胆汁淤积的发生发展中具有重要作用,逐渐成为抗胆汁淤积药物研发的热点靶标。中医药安全有效且不良反应较少,随着研究的逐步深入,中药活性成分及复方调控FXR抗胆汁淤积疗效显著。本研究通过文献检索及归纳总结,系统挖掘中药活性成分及复方基于FXR抗胆汁淤积的研究进展,以期为胆汁淤积治疗及相关药物研发提供思路和参考。Cholestasis is a pathology common to many acute and chronic liver diseases and is mainly characterized by excessive accumulation of bile components such as bile acids(BAs) in the liver and body circulation.Clinical manifestations are jaundice,fatigue and itching,etc.The condition is protracted and difficult to cure.If not intervened in time,persistent cholestasis can further develop into liver fibrosis,cirrhosis,liver failure and even end-stage liver disease.The pathogenesis of cholestasis is complex,and there is a lack of effective therapeutic drugs.Recent studies have shown that farnesol X receptor(FXR) plays an important role in the development of cholestasis by regulating the synthesis,transport,metabolism,and reabsorption of BAs,the major components of bile,and has gradually become a hot target in the research and development of anti-cholestasis drugs.Traditional Chinese medicine(TCM) is safe,effective and has few side effects,and with the gradual deepening of research,the efficacy of TCM active ingredients or combinations in regulating FXR against cholestasis is remarkable.Through literature search and summarization,the authors systematically explored the research progress of FXR receptor-based anti-cholestasis of TCM active ingredients and combinations,with a view to providing ideas and references for the treatment of cholestasis and related drug development.

关 键 词：胆汁淤积 胆汁酸 法尼醇X受体 中医药 机制 

分 类 号：R975.5[医药卫生—药品]