RNA结合蛋白HuR与非编码RNA相互作用在疾病中的研究进展  

Research progress of interaction between RNA binding protein HuR and non-coding RNA in diseases

作　　者：黄勇 袁小漫 刘凌蔚 李松沛 HUANG Yong;YUAN Xiao-man;LIU Ling-wei;LI Song-pei(School of Pharmaceutical Sciences,Key Laboratory of Molecular Target&Clinical Pharmacology,Guangzhou Medical University,Guangzhou 511436,China)

机构地区：[1]广州医科大学药学院,广东省分子靶标与临床药理重点实验室,广东广州511436

出　　处：《中国药理学通报》2025年第4期601-605,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No.J19111095)。

摘　　要：RNA结合蛋白人类抗原R(human antigen R,HuR)是胚胎致死性异常视觉样1(embryonic lethal abnormal vision-like 1,ELAVL1)基因编码的蛋白产物,在人体细胞中普遍表达,主要通过与含AU富集元件(AU-enriched elements,AREs)的mRNA结合调节mRNA稳定性来参与转录后调控。近年来,大量研究表明,HuR还可与非编码RNA(non-coding RNA,ncRNA)相互作用来参与基因表达的调控,包括长链ncRNA、环状RNA、微小RNA和穹窿体RNA等。HuR和这些ncRNA的相互作用在肿瘤等多种疾病的发生和发展中起了关键作用,由于肿瘤方面的研究已经有综述进行归纳总结,该综述主要总结HuR-ncRNA相互作用在肿瘤以外的疾病中的作用。RNA-binding protein human antigen R(HuR)is a protein product of the embryonic lethal abnormal vision gene(ELAVL).It is widely expressed in human cells and primarily regulates mRNA stability through post-transcriptional mechanisms,particularly by binding to AU-enriched elements(AREs).Recent studies have indicated that HuR interacts with non-coding RNAs to participate in the regulation of gene expression,including long non-coding RNAs,circular RNAs,microRNAs,and vault RNAs.The interactions between HuR and these ncRNAs play a crucial role in the occurrence and development of various diseases,including tumors.Since there are already reviews summarizing the research on tumors,this review mainly focuses on summarizing the role of HuR-ncRNA interactions in diseases other than tumors.

关 键 词：人类抗原R 非编码RNA MIRNA lncRNA circRNA 转录后调控 

分 类 号：R968[医药卫生—药理学] R394.3[医药卫生—药学]