15%Azelaic acid gel modify the skin microbiota of acne vulgaris  

作　　者：Wenxin Yu Huchi Shen Beilei Cai Yuanruo Xie Yue Wang Jing Wang 

机构地区：[1]School of Chemical&Material Engineering,Jiangnan University,Wuxi 214122,China [2]Sinomune PharmAceutical Co.,Ltd.,Wuxi 214122,China

出　　处：《Journal of Dermatologic Science and Cosmetic Technology》2024年第4期9-15,共7页皮肤科学与化妆品技术期刊(英文)

摘　　要：Background:Over 85%of teenagers and young adults worldwide suffer from acne vulgaris(AV),a widespread chronic condition that makes up 15–20%of all skin disease cases.Objective:For AV treatment,15%Azelaic acid gel has long been promoted as a safe and efficient therapeutic agent.Our goal was to investigate how the skin microbiota of individuals with acne vulgaris was affected by a 15%Azelaic acid gel.Materials and methods:A total of 55 volunteers who clearly displayed signs of acne vulgaris were recruited.They used a 15%Azelaic acid gel every day for 28 days,with 3 follow-up appointments on the 1st,14th,and 28th days.The V3–V4 region of the 16S rRNA gene was sequenced to examine the skin microbial samples that were collected.Results:The taxonomic makeup of the microbiome communities in acne-affected vs.acne-free locations differs significantly.The Alpha and Beta diversity of acne-affected areas improved after 28 days of applying 15%Azelaic acid gel.There were slight decreases in values of Cutibacterium and Staphylococci,which were not statistically significant.Lactobacillus increased considerably(p*=0.01)from 0.97%to 1.60%.Propionibacterium and Staphylococci relative numbers after extended usage of 15%Azelaic acid gel were similar to those of skin not affected by acne.Conclusion:15%Azelaic acid gel aided in modifying the skin microbiota within the acne vulgaris group increased the diversity of skin microbiota in the acne-affected area.

关 键 词：Acne vulgaris Skin microbiome 15%Azelaic acid gel PROPIONIBACTERIUM 

分 类 号：R751[医药卫生—皮肤病学与性病学]