基于国际昂贵抗肿瘤药物剂量舍入倡议对我国抗肿瘤药物成本节约研究  

Research on cost saving of anti-neoplastic drugs in China based on international expensive anti-neoplastic drug dose rounding initiative

作　　者：任灵芝 王婷 余文浩 唐浩淳 陆浩 孟珺 REN Lingzhi;WANG Ting;YU Wenhao;TANG Haochun;LU Hao;MENG Jun(Department of Pharmacy,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&.Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Guangdong Shenzhen 518172,China;Department of Pharmacy,the Eighth Affiliated Hospital,Sun Yat-sen University,Guangdong Shenzhen 518033,China;Intemed Hospital Management&Development Centre,Beijing 100074,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院药学部,广东深圳518172 [2]中山大学附属第八医院药学部,广东深圳518033 [3]壹正医院管理发展(北京)中心,北京100074

出　　处：《中国医院药学杂志》2025年第6期701-705,共5页Chinese Journal of Hospital Pharmacy

摘　　要：目的:对抗肿瘤药物剂量舍入方法开展研究,并评估使用剂量舍入后癌症治疗成本的节省情况,为减少抗癌成本提供依据。方法:统计中国医学科学院肿瘤医院深圳医院2023年患者使用的抗肿瘤药物剂量,运用浪费成本分析和理论剂量节约两个指标评估抗肿瘤药物节省的成本。浪费成本分析描述的是由于使用非整支药物而丢弃的药物数量;理论剂量节约描述的是将处方剂量舍入到最接近的整支药物而可能避免浪费的成本。将理论舍入剂量与处方用药剂量进行比较。结果:2023年全年共收集到67535条抗肿瘤药医嘱,对其中7311条医嘱进行了剂量舍入。剂量舍入可减少185435.15 mg抗肿瘤药物的浪费,同时可节省548277.53元成本。剂量舍入的波动范围为0.14%~10.00%。结论:在剂量舍入的偏差符合指南的前提下,对抗肿瘤药物的处方进行剂量舍入可以有效节约成本和避免药品浪费。OBJECTIVE To investigate the dose rounding method of anti-neoplastic drugs,and to evaluate the cost savings in cancer treatment,so as to provide a basis for reducing the cost of anti-cancer.METHODS The dose of anti-neoplastic drugs used by patients in Cancer Hospital,Chinese Academy of Medical Sciences,Shenzhen Center in 2023 was counted,and the cost savings of anti-neoplastic drugs were evaluated by waste-cost analysis and theoretical dose saving.The waste-cost analysis was used to describe the number of drugs discarded due to the use of partial bottle.Theoretical dose savings were applied to describe the cost that might be avoided by rounding the prescription dose to the nearest vial size.The theoretical rounding dose was compared with the prescription dose.RESULTS A total of 67535 orders of anti-neoplastic drugs were collected in 2023,of which 7311 orders were rounded.Rounding the dose could avoid the waste of 185435.15 mg anti-neoplastic drugs and save a cost of 548277.53 yuan.The rounding range was 0.14% to 10.00%.CONCLUSION On the premise that the deviation of dose rounding is in line with the guidelines,dose rounding of anti-neoplastic drugs prescriptions can effectively save costs and avoid drug waste.

关 键 词：抗肿瘤药物 剂量舍入 成本节约 

分 类 号：R979.1[医药卫生—药品]