Harnessing medicinal plants: New hope for typhoid fever antibacterial agents - Mini review  

作　　者：Ifeoluwa Margaret Idowu Tian-Xiang Li Emmanuel Adikwu Orgah John Osilama Thomas Kayode Olaoluwa Olaniyan Yu-Zhou Chen Abel Oguntoyinbo Sunitha Ganesha Rudrapatna 

机构地区：[1]School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [2]Nigeria Natural Medicine Development Agency,Lagos 101241,Nigeria [3]Department of Veterinary Parasitology and Entomology,College of Veterinary Medicine,Federal University of Agriculture,Abeokuta 110111,Nigeria [4]School of Chinese and western clinical medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《Natural Therapy Advances》2025年第1期36-54,共19页

摘　　要：Typhoid fever remains a major global health challenge,particularly in regions with limited access to clean water and sanitation.The emergence of multidrug-resistant and extensively drug-resistant strains of Salmonella enterica serovar Typhi highlights the urgent need for alternative treatment strategies.Medicinal plants represent a promising avenue for addressing this crisis,as their bioactive compounds exhibit potent antibacterial properties.According to the World Health Organization,over 20,000 medicinal plant species have been identified as valuable resources for drug discovery,with more than 1,340 demonstrating antimicrobial activity and over 30,000 antimicrobial compounds isolated.Through an extensive review,key phytochemicals with anti-typhoid properties were identified,along with their mechanisms of action and supporting evidence from in vitro and in vivo studies.This review compiles data on plants with demonstrated anti-typhoid activity,highlights challenges such as standardization,regulatory frameworks,and integration into modern healthcare,and explores the role of omics technologies in advancing the discovery of novel plant-based antimicrobial agents.By discussing potential medicinal plant targets and intervention strategies,this work lays the groundwork for future research into plant-derived anti-infective therapies and contributes to the global effort to combat the growing threat of typhoid fever,particularly in resource-limited settings.

关 键 词：typhoid fever medicinal plants PHYTOCHEMICALS antimicrobial resistance 

分 类 号：R285[医药卫生—中药学] R28[医药卫生—中医学]