冠心病与溃疡性结肠炎之间的因果关系:一项孟德尔随机化研究  

Causality between coronary heart disease and ulcerative colitis:a Mendelian randomization study

作　　者：张雨晗 刘兴德 郑玉华 雷雨 熊晓满 吴闵 ZHANG Yuhan;LIU Xingde;ZHENG Yuhua;LEI Yu;XIONG Xiaoman;WU Min(Department of Cardiovascular Medicine,Second Clinical College of Guizhou University of Chinese Medicine,Guiyang 550003,China;Department of Cardiovascular Medicine, Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine;Blood Transfusion Laboratory,Guizhou Blood Center;Department of Gastroenterology, First Affiliated Hospital of Guizhou University of Chinese Medicine)

机构地区：[1]贵州中医药大学第二临床医学院心血管内科,贵阳550003 [2]贵州中医药大学第二附属医院心血管内科 [3]贵州省血液中心输血研究室 [4]贵州中医药大学第一附属医院消化内科

出　　处：《山西医科大学学报》2025年第3期252-256,共5页Journal of Shanxi Medical University

基　　金：国家自然科学基金资助项目(82060855);贵州省高等学校中西医结合防治疾病转化医学重点实验室项目(黔教技[2023]017号)。

摘　　要：目的采用孟德尔随机化分析方法探讨冠心病与溃疡性结肠炎(ulcerative colitis,UC)之间的因果关联。方法从全基因组关联研究(genome-wide association study,GWAS)汇总数据中筛选与冠心病相关的单核苷酸多态性(single nucleotic polymorphism,SNP)作为基因工具变量,主要分析方法采用逆方差加权法(inverse variance weighted,IVW)评估冠心病对溃疡性结肠炎的效应,用MR-Egger回归、加权中位数法(weighted median,WM)、简单模式(simple mode)和加权模式(weighted mode)来检验结果的稳健型。通过异质性分析、多效性分析及敏感性分析进一步验证结果的可靠性和稳定性。结果共筛选得35个SNP作为工具变量,IVW法分析显示,冠心病与溃疡性结肠炎之间存在正相关关系(OR=1.16,95%CI 1.04~1.29,P<0.05),提示冠心病可能会增加溃疡性结肠炎的患病风险。WM分析也显示出类似的结果(OR=1.23,95%CI 1.05~1.45,P<0.05)。此外,Cochrane Q检验、MR-Egger回归截距和漏斗图结果显示,未发现异质性和水平多效性,结果具有可靠性。结论冠心病可能会诱发溃疡性结肠炎,两者之间存在正向因果关联。Objective To explore the causal association between coronary heart disease(CHD)and ulcerative colitis(UC)using Mendelian randomization analysis.Methods Single nucleotide polymorphism(SNP)associated with CHD was selected from the data in the genome-wide association study(GWAS)as an instrumental variable.Inverse variance weighted(IVW)method was used to evaluate the effect of coronary heart disease on ulcerative colitis.MR-Egger regression,weighted median(WM),simple mode method and weighted mode method were used to analyze the robustness of the results.The reliability and the stability of the results were further verified by heterogeneity analysis,pleiotropy analysis and sensitivity analysis.Results A total of 35 SNPs were selected as instrumental variables,and IVW results revealed a positive correlation between CHD and UC(OR=1.16,95%CI 1.04-1.29,P<0.05),suggsting that CHD may increase the risk of UC.WM result was similar to IVM result(OR=1.23,95%CI 1.05-1.45,P<0.05).Cochrane Q test,MR-Egger intercept assessment and funnel plot results revealed no heterogeneity or horizontal multicollinearity,and the results were reliable.Conclusion This study suggests that coronary heart disease may induce the ulcerative colitis,and there is a positive causal association between the two.

关 键 词：冠心病 溃疡性结肠炎 孟德尔随机化 单核苷酸多态性 因果效应 全基因组关联研究 

分 类 号：R541.4[医药卫生—心血管疾病]