移植肾原发性肾小球疾病复发临床诊疗指南  

Guidelines for the diagnosis and treatment of recurrent primary glomerular disease in kidney transplantation

作　　者：中华医学会器官移植学分会 文吉秋 刘龙山[3] 李宁 王维 伍倩倩 陈文芳[3] 谢楠 秦燕[8] Branch of Organ Transplantation,Chinese Medical Association;Wen Jiqiu(不详;the Second Affiliated Hospital of Guangri Medical University,Nanning 530005)

机构地区：[1]不详 [2]广西医科大学第二附属医院,南宁530005 [3]中山大学附属第一医院 [4]山西省第二人民医院 [5]上海市第十人民医院 [6]东南大学附属中大医院 [7]中国人民解放军东部战区总医院 [8]上海市第一人民医院

出　　处：《中华器官移植杂志》2025年第2期85-105,共21页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金(81570681)。

摘　　要：原发病复发是降低移植肾近期和远期存活率的重要原因,越来越受到重视。原发病为原发性肾小球肾炎的肾脏移植受者移植术后有不同程度复发风险,可对移植肾造成损害。随着对自体肾原发性肾小球疾病发病机制的深入认识,移植肾原发性肾小球疾病复发的诊疗水平也在逐布提升。中华医学会器官移植学分会组织器官移植专家,充分阅读、分析和总结目前国际和国内的文献,在《慢性移植肾功能不全诊疗规范(2019版)》的基础上,对移植肾原发性肾小球疾病复发的风险、预防措施、复发的诊疗措施及预后等内容,依据推荐评估、发展和评价分级方法对证据质量和建议强度进行客观评估,制定《移植肾原发性肾小球疾病复发临床诊疗指南》,在本指南中对相应临床问题提出推荐意见,以提升肾移植受者和移植肾存活率。Recurrent primary disease is a significant factor contributing to both short-term and long-term graft loss in kidney transplantation and has been receiving increasing attention.Kidney transplant recipients with primary glomerulonephritis face varying degrees of recurrence risk post-transplant,leading to allograft injury.With advancements in the understanding of the pathogenesis of primary glomerular disease in native kidneys,the diagnosis and treatment of recurrent glomerular disease in kidney allografts have also been improving.The Organ Transplantation Branch of the Chinese Medical Association organized experts in organ transplantation to comprehensively review,analyze,and summarize current international and domestic literature.Based on the 2019 Guidelines for the Diagnosis and Treatment of Chronic Kidney Transplant Dysfunction,they formulated the Guidelines for the Diagnosis and Treatment of Recurrent Primary Glomerular Disease in Kidney Transplantation.This guideline objectively assesses the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)methodology.It addresses key aspects such as the risk of recurrence of primary glomerular disease in kidney transplants,preventive strategies,diagnostic and therapeutic approaches,and prognosis.By providing evidence-based recommendations on these clinical issues,this guideline aims to improve the survival rates of both kidney transplant recipients and their allografts.

关 键 词：肾脏移植 原发性肾小球疾病 移植肾原发病复发 治疗 指南 

分 类 号：R699.2[医药卫生—泌尿科学]