替格瑞洛不良反应87例分析  

Analysis of 87 Cases of Adverse Reactions of Ticagrelor

作　　者：庞丽[1] 陈永妍[1] 杨玉玲[1] PANG Li;CHEN Yongyan;YANG Yuling(Department of Pharmacy,the 7th People's Hospital of Zhengzhou,Zhengzhou 450016,Henan,China)

机构地区：[1]郑州市第七人民医院药学部,河南郑州450016

出　　处：《中国药物滥用防治杂志》2025年第2期233-235,248,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20220851)。

摘　　要：目的:分析郑州市第七人民医院87例口服替格瑞洛患者发生不良反应情况。方法:选择郑州市第七人民医院在国家药品不良反应监测系统中2021年1月1日—2024年5月31日上报的87例替格瑞洛不良反应报告进行统计分析,包括患者基本信息、用药信息、不良反应发生情况、不良反应结果。结果:不良反应报告类型严重、一般的患者在性别、年龄、民族、体重方面比较,差异无统计学意义(P>0.05)。87例替格瑞洛不良反应患者中4例口服90 mg/次,1例口服120mg/次,82例口服180 mg/次。87例替格瑞洛不良反应患者用药开始至不良反应发生时间0~13d,平均用药开始至不良反应发生时间(3.05±2.24)d。87例替格瑞洛不良反应中呼吸系统的不良反应显著,占了所有不良反应的96.55%,特别是胸闷(65.52%)和气短(14.94%)。87例替格瑞洛不良反应中呼吸系统的不良反应,大多数患者(97.70%)的不良反应在治疗或管理后得到了不同程度的缓解或痊愈,未好转的比例较低(2.30%)。结论:我院87例口服替格瑞洛后发生不良反应的患者中以呼吸系统不良反应最为显著,大多数患者的不良反应在治疗或管理后得到了不同程度的缓解或痊愈,未好转的比例较低。因此,在使用替格瑞洛过程中,医务人员需密切关注患者的不良反应情况,并采取及时有效的治疗和管理措施,以减轻患者的不适,提高患者的生活质量。Objective:To analyze the adverse reactions of 87 patients with oral ticagrelor in the 7th People's Hospital of Zhengzhou.Methods:A total of 87 adverse reaction reports of ticagrelor reported by the 7th People's Hospital of Zhengzhou in the National Adverse Reaction Monitoring System from January 1,2021 to May 31,2024 were selected for statistical analysis,including patient basic information,medication information,occurrence of adverse reactions,and adverse reaction results.Results:There was no significant difference in gender,age,nationality and weight between patients with severe and general adverse reaction reports(P>0.05).Among 87 patients with adverse reactions of ticagrelor,4 patients took 90 mg/time orally,1 patient took 120 mg/time orally,and 82 patients took 180 mg/time orally.The time from the start of medication to the occurrence of adverse reactions in 87 patients with adverse reactions of ticagrelor was 0-13 days,and the average time from the start of medication to the occurrence of adverse reactions was(3.05±2.24)days.Among the 87 cases of ticagrelor adverse reactions,the adverse reactions of the respiratory system were significant,accounting for 96.55%of all adverse reactions,especially chest tightness(65.52%)and shortness of breath(14.94%).Among the 87 cases of adverse reactions of ticagrelor,most patients(97.70%)had different degrees of remission or recovery after treatment or management,and the proportion of unimproved patients was low(2.30%).Conclusion:Among the 87 patients with adverse reactions after oral ticagrelor in our hospital,the respiratory adverse reactions were the most significant.The adverse reactions of most patients were relieved or cured to varying degrees after treatment or management,and the proportion of unimproved was low.Therefore,in the process of using ticagrelor,medical staff should pay close attention to the adverse reactions of patients,and take timely and effective treatment and management measures to reduce the discomfort of patients and improve the quality of life o

关 键 词：替格瑞洛 不良反应 合理用药 

分 类 号：R969.3[医药卫生—药理学]