抗肿瘤药物临床合理应用过程中开展药师全面干预的效果  

Effect of Comprehensive Intervention of Pharmacists in the Process of Clinical Rational Application of Antitumor Drugs

作　　者：龚旭淳 徐美亚[1] 许艳[1] 苏燕[1] 钱健 GONG Xuchun;XU Meiya;XU Yan;SU Yan;QIAN Jian(Department of Pharmacy,the Second People's Hospital of Changshu,Changshu 215500,Jiangsu,China)

机构地区：[1]江苏省常熟市第二人民医院药学部,江苏常熟215500

出　　处：《中国药物滥用防治杂志》2025年第2期239-241,共3页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：苏州科技计划指导项目(编号:SKYXD2022004)。

摘　　要：目的:探讨药师对临床合理应用抗肿瘤药物的干预效果。方法:回顾性选取2022年7月—12月未开展药师全面干预的抗肿瘤药物医嘱256份设为对照组,将2023年7月—12月开展全面干预后的抗肿瘤药物医嘱256份设为观察组。对比两组不合理医嘱发生情况、不合理医嘱分布类型并对抗肿瘤药物不合理医嘱情况予以具体分析。结果:相较于对照组(25.00%),观察组不合理医嘱发生率(7.42%)较低(P<0.05);相较于对照组,观察组不合理医嘱中抗肿瘤药物预处理不规范、止吐药物使用时机不规范、辅助用药使用不规范、抗肿瘤药物使用及注射时间不规范发生率均较低(P<0.05);抗肿瘤药物不合理医嘱具体以紫杉醇等药物的预处理不规范、依托泊苷药物浓度不规范及昂丹司琼给药时机不恰当等为主,其中对照组昂丹司琼给药时机不恰当显著高于观察组(P<0.05)。结论:药师全面干预后对抗肿瘤药物的临床合理应用具有一定的临床价值,能有效促进抗肿瘤药物不合理医嘱发生率的降低,确保患者的治疗效果和安全性。Objective:To probe into the intervention effect of pharmacists on rational use of anti-tumor drugs in clinic.Methods:A total of 256 anti-tumor drug orders without comprehensive intervention by pharmacists from July to December 2022 were retrospectively selected as the control group,and 256 antitumor drug orders after comprehensive intervention from July to December 2023 were set as the observation group.The occurrence of unreasonable medical orders,the distribution types of unreasonable medical orders and the unreasonable medical orders of anti-tumor drugs were compared between the two groups.Results:Compared with the control group(25.00%),the incidence of unreasonable medical orders in the observation group(7.42%)was lower(P<0.05);compared with the control group,the incidence of irregular pretreatment of anti-tumor drugs,irregular use of antiemetic drugs,irregular use of adjuvant drugs,irregular use of anti-tumor drugs and irregular injection time in the observation group was lower(P<0.05).The unreasonable medical orders of anti-tumor drugs were mainly the non-standard pretreatment of drugs such as paclitaxel,the non-standard concentration of etoposide and the inappropriate timing of ondansetron administration.The inappropriate timing of ondansetron administration in the control group was significantly higher than that in the observation group(P<0.05).Conclusion:The clinical rational application of anti-tumor drugs after comprehensive intervention of pharmacists has certain clinical value,which can effectively promote the reduction of the incidence of unreasonable medical orders of anti-tumor drugs and ensure the therapeutic effect and safety of patients.

关 键 词：抗肿瘤药物 合理用药 药师干预 

分 类 号：R95[医药卫生—药学]