间苯三酚联合盐酸坦洛新治疗输尿管下段结石导致肾绞痛的效果  

Effect of Phloroglucinol Combined with Tamsulosin Hydrochloride in the Treatment of Renal Colic Caused by Lower Ureteral Calculi

作　　者：张媛媛[1] 苏萍[1] 梁亚慧[1] 刘娜[1] 朱永敏[1] 刘源[2] ZHANG Yuanyuan;SU Ping;LIANG Yahui;LIU Na;ZHU Yongmin;LIU Yuan(Department of Urinary surgery,Shangqiu First People's Hospital,Shangqiu 476000,Henan,China;Department of Pharmaceutics,Shangqiu First People's Hospital,Shangqiu 476000,Henan,China)

机构地区：[1]商丘市第一人民医院泌尿外科,河南商丘476000 [2]商丘市第一人民医院药学部,河南商丘476000

出　　处：《中国药物滥用防治杂志》2025年第2期277-279,共3页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20210992)。

摘　　要：目的:分析间苯三酚联合盐酸坦洛新治疗输尿管下段结石导致肾绞痛的临床疗效。方法:选取我院于2023年6月—2024年5月期间收治的96例输尿管下段结石患者进行研究,依据随机数字表法原则分为参照组与实验组,每组48例。参照组给予间苯三酚治疗,实验组采用间苯三酚联合盐酸坦洛新进行治疗。比较两组疼痛评分、肾绞痛情况及结石排出率、临床疗效、不良反应。结果:实验组治疗后30 min、1 h、4 h的VAS评分均低于参照组(P<0.05);实验组肾绞痛发作次数少于参照组,发作持续时间短于参照组,结石排出率高于参照组(P<0.05);实验组治疗有效率为97.72%,高于参照组的64.58%(P<0.05);实验组不良反应发生率为4.17%,低于参照组的18.75%(P<0.05)。结论:在输尿管下段结石导致肾绞痛治疗中,间苯三酚联合盐酸坦洛新治疗更利于缓解患者疼痛,减少肾绞痛发作频率,提高结石排出率和临床治疗有效性,且安全性更高。Objective:To analyze the clinical efficacy of phloroglucinol combined with tamsulosin hydrochloride in the treatment of renal colic caused by lower ureteral calculi.Methods:A total of 96 patients with lower ureteral calculi admitted to our hospital from June 2023 to May 2024 were selected for study.According to the principle of random number table method,they were divided into reference group and experimental group,with 48 patients in each group.The reference group was treated with phloroglucinol,and the experimental group was treated with phloroglucinol combined with tamsulosin hydrochloride.The pain score,renal colic,stone discharge rate,clinical efficacy and adverse reactions were compared between the two groups.Results:The VAS score of the experimental group at 30 min,1 h and 4 h after treatment was lower than that of the reference group(P<0.05).The number of renal colic attacks in the experimental group was less than that in the reference group,the duration of the attack was shorter than that in the reference group,and the stone discharge rate was higher than that in the reference group(P<0.05).The effective rate of treatment in the experimental group was 97.72%,which was higher than 64.58%in the reference group(P<0.05).The incidence of adverse reactions in the experimental group was 4.17%,which was lower than 18.75%in the reference group(P<0.05).Conclusion:In the treatment of renal colic caused by lower ureteral calculi,phloroglucinol combined with tamlosin hydrochloride is more beneficial to relieve patients'pain,reduce the frequency of renal colic,improve stone discharge rate and clinical treatment effectiveness,with higher safety.

关 键 词：间苯三酚 盐酸坦洛新 输尿管下段结石 肾绞痛 疗效 安全性 

分 类 号：R692[医药卫生—泌尿科学] R691.4[医药卫生—外科学]