口服米非司酮辅助口服维生素B_(1)联合羊膜腔内注射乳酸依沙吖啶在孕中期引产的效果  

Effect of Oral Mifepristone Combined with Oral Vitamin B_(1)Combined with Amniotic Cavity Injection of Ethacridine Lactate on Induction of Labor in the Second Trimester of Pregnancy

作　　者：梁霜 赵广蕊 LIANG Shuang;ZHAO Guangrui(Department of Obstetrics,the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院产科,河南南阳473000

出　　处：《中国药物滥用防治杂志》2025年第2期299-301,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探究羊膜腔内注射乳酸依沙吖啶联合米非司酮、维生素B_(1)在孕中期引产过程中的临床效果。方法:选取我院2019年9月—2024年6月168例孕中期需引产患者作为研究对象,根据治疗方案不同分为观察组、对照组,每组84例。对照组给予羊膜腔内注射乳酸依沙吖啶联合口服维生素B_(1)进行引产,观察组基于对照组给予米非司酮片进行引产。比较两组用药后引产效果、引产成功率、清宫率、并发症发生率。结果:相比于对照组,观察组宫缩启动时间、引产时间更短,产后失血量更少(P<0.05);用药后72h内与对照组相比,观察组引产成功率更高(P<0.05);用药后72h内观察组清宫率为14.29%,低于对照组的36.90%(P<0.05);与对照组相比,观察组产后并发症发生率更低(P<0.05)。结论:羊膜腔内注射乳酸依沙吖啶联合米非司酮、维生素B_(1)应用于孕中期引产过程中,可使孕中期引产顺利进行,增加引产成功率,降低清宫率及产后并发症发生率。Objective:To explore the clinical effect of amniotic cavity injection of ethacridine lactate combined with mifepristone and vitamin B_(1)in the induction of labor in the second trimester.Methods:From September 2019 to June 2024,168 patients who needed induction of labor in the second trimester of pregnancy in our hospital were selected as the research objects.According to different treatment schemes,they were divided into observation group and control group,with 84 patients in each group.The control group was given intra-amniotic injection of ethacridine lactate combined with oral vitamin B_(1)for induction of labor,and the observation group was given mifepristone tablets for induction of labor based on the control group.The effect of induced labor,the success rate of induced labor,the rate of uterine curettage and the incidence of complications were compared between the two groups.Results:Compared with the control group,the uterine contraction start time and induction time of the observation group were shorter,and the postpartum blood loss was less(P<0.05).Compared with the control group,the success rate of induced labor in the observation group was higher within 72 hours after administration(P<0.05).The curettage rate of the observation group within 72 hours after medication was 14.29%,which was lower than 36.90%of the control group(P<0.05).Compared with the control group,the incidence of postpartum complications in the observation group was lower(P<0.05).Conclusion:The application of amniotic cavity injection of ethacridine lactate combined with mifepristone and vitamin B_(1)in the process of induction of labor in the second trimester can make the induction of labor in the second trimester go smoothly,increase the success rate of induction of labor,and reduce the rate of uterine curettage and the incidence of postpartum complications.

关 键 词：米非司酮 维生素B_(1) 乳酸依沙吖啶 孕中期引产 

分 类 号：R719.3[医药卫生—妇产科学]