盐酸羟考酮用于全麻手术患者超前镇痛的临床研究  

Clinical Study on Oxycodone Hydrochloride for Preemptive Analgesia in Patients Undergoing General Anesthesia Surgery

作　　者：马树兴 陈峻[1] 曾春陆[1] 李欢 黄格[1] Ma Shuxing;Chen Jun;Zeng Chunlu;Li Huan;Huang Ge(Guangxi Zhuang Autonomous Region Ethnic Hospital,Nanning,Guangxi 530000)

机构地区：[1]广西壮族自治区民族医院,广西南宁530000

出　　处：《中外健康》2024年第5期45-47,共3页

摘　　要：探讨盐酸羟考酮用于全麻手术患者超前镇痛的临床效果。选取2022年8月―2023年6月期间在广西壮族自治区民族医院接受气管插管全麻手术的200例患者,采用随机数字表法将其分为对照组和观察组,每组各100例。两组患者均采用气管插管静吸复合全身麻醉,对照组在麻醉诱导前静脉注射5 mL生理盐水,观察组在麻醉诱导前静脉注射5mL含0.05mg/kg盐酸羟考酮的溶液,比较两组的血流动力学指标、麻醉恢复时间、并发症发生率及术后疼痛程度。研究结果显示,插管前1min、插管即刻、插管后1min、插管后5min,观察组血流动力学指标均显著优于对照组(P<0.05);观察组麻醉恢复时间均显著短于对照组,术后并发症发生率和术后疼痛评分均显著低于对照组(P<0.05)。研究发现,在全麻手术前静脉注射盐酸羟考酮能够有效稳定患者的血流动力学指标,缩短麻醉恢复时间,降低术后并发症发生率,并显著减轻术后疼痛症状。To explore the clinical efficacy of hydrocodone hydrochloride for preemptive analgesia in patients undergoing general anesthesia surgery.Select 200 patients who underwent general anesthesia with endotracheal intubation at Guangxi Zhuang Autonomous Region Ethnic Hospital from August 2022 to June 2023,and use a random number table method to divide them into a control group and an observation group,with 100 patients in each group.Both groups of patients received endotracheal intubation combined with general anesthesia.The control group received intravenous injection of 5 mL of physiological saline before anesthesia induction,while the observation group received intravenous injection of 5 mL of a solution containing 0.05 mg/kg hydrocodone hydrochloride before anesthesia induction.The hemodynamic indicators,anesthesia recovery time,incidence of complications,and postoperative pain level of the two groups were compared.The research results showed that the hemodynamic indicators of the observation group were significantly better than those of the control group at 1 minute before intubation,immediately after intubation,1 minute after intubation,and 5 minutes after intubation(P<0.05);The recovery time of anesthesia in the observation group was significantly shorter than that in the control group,and the incidence of postoperative complications and postoperative pain scores were significantly lower than those in the control group(P<0.05).Research has found that intravenous injection of hydrocodone hydrochloride before general anesthesia surgery can effectively stabilize patients'hemodynamic indicators,shorten anesthesia recovery time,reduce the incidence of postoperative complications,and significantly alleviate postoperative pain symptoms.

关 键 词：全麻手术 盐酸羟考酮 生理盐水 超前镇痛 血流动力学 

分 类 号：R614.2[医药卫生—麻醉学]