胰高血糖素样肽⁃1受体激动剂相关心率加快的研究进展  

Research progress of increased heart rate related to glucagon-like peptide-1 receptor agonists

作　　者：王丽 张旭升 任秀丽 沈承武 卢翠翠 Wang Li;Zhang Xusheng;Ren Xiuli;Shen Chengwu;Lu Cuicui(Department of Pharmacy,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji′nan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院药学部,济南250021

出　　处：《药物不良反应杂志》2025年第3期182-187,共6页Adverse Drug Reactions Journal

基　　金：山东省药品化妆品不良反应监测哨点课题(2022SDADRKY01);山东省医学会临床药学科研专项(YXH2022ZX001)。

摘　　要：胰高血糖素样肽⁃1受体激动剂(GLP⁃1RA)广泛用于2型糖尿病(T2DM)的治疗,其导致的心率加快不容忽视。在一般人群和糖尿病患者中,心率加快与心血管疾病的患病率及病死率具有独立相关性。一般来说,长效GLP⁃1RA对心率的影响更大,心率的增加呈剂量依赖性且与基线水平心率呈负相关。GLP⁃1RA导致的心率增加可能与增强交感神经活动、诱发血管舒张引起的反射性心动过速等有关。临床使用GLP⁃1RA时,应注意该药可致的心率加快,尤其对于有心血管疾病高危因素的患者。若患者出现明显心率加快,需尽快停用GLP⁃1RA,必要时给予对症治疗。Glucagon⁃like peptide⁃1 receptor agonists(GLP⁃1RA)have been widely used in the treatment of type 2 diabetes mellitus(T2DM).However,the acceleration of heart rate caused by GLP⁃1RA should not be ignored.In the general population and patients with diabetes,increased heart rate has an inde⁃pendent correlation with the incidence and mortality of cardiovascular diseases.In general,the long⁃acting GLP⁃1RA seem to exert a greater effect in increasing heart rate,and the effect is dose⁃dependent and nega⁃tively correlated with baseline heart rate.The increase in heart rate caused by GLP⁃1RA may be related to enhanced sympathetic nervous activity,reflex tachycardia as a response to vasodilation,etc.It is advisable to closely monitor the increased heart rate induced by GLP⁃1RA in clinical practice,especially in patients with high⁃risk factors for cardiovascular disease.In case of elevated heart rate,the management begins with imme⁃diate discontinuation of the GLP⁃1RA and symptomatic intervention should be given if necessary.

关 键 词：胰高血糖素样肽⁃1 糖尿病 2型 心率 药物相关性副作用和不良反应 胰高血糖素样肽⁃1受体激动剂 

分 类 号：R587.1[医药卫生—内分泌]