替米沙坦联合5-氨基水杨酸结合微小气候因素对原发性高血压合并炎症性肠病患者血压的影响分析  

Effect of telmisartan,5-aminosalicylic acid and microclimatic factors in combination on blood pressure in patients with essential hypertension complicated with inflammatory bowel disease

作　　者：许翠萍 高慧芹 郭航燕 吴康杨 马水晶 XU Cui-ping;GAO Hui-qin;GUO Hang-yan;WU Kang-yang;MA Shui-jing(Graduate School,Zhejiang Chinese Medical University,Hangzhou,Zhejiang 310056,China;不详)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310056 [2]东阳市红会医院内科 [3]涡阳县人民医院消化内科

出　　处：《环境与健康杂志》2025年第2期164-167,共4页Journal of Environment and Health

摘　　要：目的探讨替米沙坦联合5-氨基水杨酸结合微小气候因素对原发性高血压合并炎症性肠病患者血压的影响。方法采用前瞻性研究,选取2021年1月至2023年1月东阳市红会医院收治的98例原发性高血压合并炎症性肠病患者,随机分为研究组和对照组各49例。对照组给予口服替米沙坦(20~80 mg/d,根据血压反应调整)。研究组在对照组基础上加用5-氨基水杨酸(每日3次,每次1 g),并结合微小气候因素进行个体化干预。两组均治疗12周。比较干预前后两组患者血压、Mayo评分、CDAI评分、HAMA和HAMD评分以及炎症因子水平。分析微小气候因素与血压控制的相关性。结果干预后,研究组患者收缩压、舒张压、心率下降均优于对照组,差异有统计学意义(P<0.05)。研究组不良事件发生低于对照组,差异有统计学意义(P<0.05)。研究组Mayo、CDAI评分及HAMA、HAMD评分均低于对照组,差异有统计学意义(P<0.05)。研究组炎症因子水平改善更明显,差异有统计学意义(P<0.05)。室内温度与收缩压呈负相关,室内相对湿度与舒张压呈正相关,气压变化与血压波动呈正相关(P<0.05)。结论替米沙坦联合5-氨基水杨酸结合微小气候因素干预可有效改善原发性高血压合并炎症性肠病患者的血压,减轻炎症反应,降低不良事件发生,提高生活质量,改善负性情绪。Objective To understand the effect oftelmisartan,5-aminosalicylic acid and microclimatic factors in combination on blood pressure in patients with essential hypertension complicated with inflammatory bowel disease.Methods 98 patients with essential hypertension combined with inflammatory bowel disease admitted to our hospital from January 2021 to January 2023 were chosen and randomly divided into study group and control group,49 in each group.The control group was given oral telmisartan(20-80 mg/d,adjusted according to blood pressure response).In the study group,5-aminosalicylic acid(1g,tid)was added to the control group and individualized intervention was carried out in combination with micro-climatic factors.Both groups were treated for 12 weeks.The blood pressure,Mayo score,CDAI score,HAMA and HAMD score,and levels of inflammatory factors were compared between the two groups before and after intervention.The correlation between microclimatic factors and blood pressure control was analyzed.Results After intervention,systolic blood pressure,diastolic blood pressure and heart rate in the study group were better than those in the control group(P<0.05).The incidence of adverse events in the study group was lower than that in the control group(P<0.05).The scores of Mayo,CDAI and HAMA and HAMD in the study group were lower than those in the control group(P<0.05).The level of inflammatory factors in the study group was significantly improved(P<0.05).Indoor temperature was negatively correlated with systolic blood pressure,indoor humidity was positively correlated with diastolic blood pressure,and barometric pressure was positively correlated with blood pressure fluctuation(P<0.05).Conclusion Telmisartan,5-aminosalicylic,micro-climatic factors in combination can effectively improve the blood pressure of patients with essential hypertension complicated with inflammatory bowel disease,reduce the incidence of adverse events,improve the quality of life and improve negative emotions.

关 键 词：替米沙坦 5-氨基水杨酸 微小气候因素 原发性高血压 炎症性肠病 

分 类 号：R45[医药卫生—治疗学]