血管内介入栓塞术治疗脑动脉瘤的效果及对患者血清炎性因子水平及神经功能的影响  

Therapeutic effect of interventional endovascular embolization on cerebral aneurysm and its influence on serum inflammatory factors levels and neurological function

作　　者：王德群 刘海巍 宋孝政 陈辉 Wang Dequn;Liu Haiwei;Song Xiaozheng;Chen Hui(Department of Neurosurgery,the First People’s Hospital of Zhumadian,Zhumadian 463000,China)

机构地区：[1]驻马店市第一人民医院神经外科,驻马店463000

出　　处：《中国实用医刊》2025年第3期44-47,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血管内介入栓塞术治疗脑动脉瘤的效果,分析血管内介入栓塞对患者血清炎性因子水平及神经功能的影响。方法前瞻性研究。抽取2021年4月至2023年3月驻马店市第一人民医院收治的96例脑动脉瘤患者,按随机数字表法分为对照组和观察组,每组48例。对照组采用显微镜下脑动脉瘤夹闭术,观察组采用血管内介入栓塞术。比较两组术前及术后1周血清炎症因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)]水平、术前及术后1个月神经功能恢复状况[美国国立卫生院卒中量表(NIHSS)评分]、术后并发症发生情况。结果术后1周,两组血清IL-6、CRP、TNF-α水平下降,且观察组血清IL-6、CRP、TNF-α水平低于对照组(P<0.05)。术后1个月,两组NIHSS评分均下降,且观察组NIHSS评分低于对照组(P<0.05)。观察组术后并发症发生率(8.33%,4/48)低于对照组(22.92%,11/48),P<0.05。结论血管内介入栓塞术用于脑动脉瘤病治疗,可有效降低血清炎症因子水平,促进患者脑神经功能恢复,术后并发症发生率较低。Objective To investigate the effect of interventional endovascular embolization in the treatment of cerebral aneurysm,and to analyze the influence on serum levels of inflammatory factors and neurological function in patients.MethodsA prospective study was conducted,including 96 patients with cerebral aneurysms who received treatment in the First People’s Hospital of Zhumadian from April 2021 to March 2023.And the 96 selected patients were divided into a control group and an observation group using a random number table method,with 48 cases in each group.The control group underwent microsurgical clipping of cerebral aneurysm,while the observation group underwent interventional endovascular embolization.The preoperative and 1-week postoperative levels of serum inflammatory factors including interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α),preoperative and 1-month postoperative neurological function evaluated by American National Institutes of Health stroke scale(NIHSS),and postoperative complications of the two groups were compared.ResultsOne week after surgery,the serum levels of IL-6,CRP,and TNF-αin the two groups decreased,while the serum levels of IL-6,CRP,and TNF-αin the observation group were lower than those in the control group(P<0.05).One month after surgery,the NIHSS scores of both groups decreased,and the NIHSS score of the observation group was lower than that of the control group(P<0.05).The incidence of postoperative complications in the observation group(8.33%,4/48)was lower than that in the control group(22.92%,11/48),P<0.05.ConclusionsInterventional endovascular embolization for the treatment of cerebral aneurysms can effectively reduce serum levels of inflammatory factors,promote the recovery of neurological function in patients,and reduce the incidence of postoperative complications.

关 键 词：颅内动脉瘤 血管内介入栓塞术 显微镜下脑动脉瘤夹闭术 炎症因子 神经功能 

分 类 号：R651.1[医药卫生—外科学] R743[医药卫生—临床医学]