曲美他嗪联合阿托伐他汀钙治疗冠心病不稳定型心绞痛的效果分析  

Effect analysis of trimetazidine combined with atorvastatin calcium in the treatment of unstable angina pectoris of coronary heart disease

作　　者：包鑫 许蕊 Bao Xin;Xu Rui(Department of Cardiovascular Medicine,People’s Liberation Army Air Force 986 Hospital,Xi’an 710000,China;Department of Critical Care Medicine,Xi’an International Medical Center Hospital,Xi’an 710000,China)

机构地区：[1]中国人民解放军空军第九八六医院心血管内科,西安710000 [2]西安国际医学中心医院重症医学科,西安710000

出　　处：《中国实用医刊》2025年第3期97-100,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨冠心病不稳定型心绞痛患者采用曲美他嗪联合阿托伐他汀钙治疗的效果及对血脂、心功能和炎症因子水平的影响。方法队列研究。抽取2019年1月至2024年2月中国人民解放军空军第九八六医院收治的冠心病不稳定型心绞痛患者90例为研究对象,按信封法分为对照组与观察组,每组45例。对照组采用阿托伐他汀钙治疗,观察组在对照组基础上联合曲美他嗪治疗,两组均完成4周治疗。比较两组血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平、心功能[6 min步行试验距离(6MWD)、左心室射血分数(LVEF)、左心室舒张末内径(LVEDd)、左室后壁厚度(LVPWT)]、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、单核细胞趋化蛋白-1(MCP-1)]水平和药物安全性。结果干预后,两组血脂水平均得到改善,且观察组TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.05)。干预后,两组心功能均得到提高,且观察组LVPWT、LVEDd低于对照组,6MWD、LVEF高于对照组(P<0.05)。干预后,两组炎症因子水平均低于治疗前,且观察组TNF-α、IL-6、MCP-1水平低于对照组(P<0.05)。两组药物安全性比较差异未见统计学意义(P>0.05)。结论曲美他嗪联合阿托伐他汀钙治疗冠心病不稳定型心绞痛效果良好,能改善患者血脂水平,降低机体内炎症级联反应,患者心功能水平得到提高,且未增加不良反应发生率。Objective To investigate the effect of trimetazidine combined with atorvastatin calcium in the treatment of unstable angina pectoris of coronary heart disease,and to analyze its effect on blood lipid,cardiac function and inflammatory factors.MethodsA total of 90 patients with unstable angina pectoris of coronary heart disease admitted to People’s Liberation Army Air Force 986 Hospital from January 2019 to February 2024 were selected as the research objects for the cohort study.According to the envelope method,they were divided into the control group and the observation group,with 45 cases in each group.The control group was treated with atorvastatin calcium,and the observation group was treated with trimetazidine based on the treatment of the control group.Both groups were treated for 4 weeks.The levels of blood lipid,including total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C),cardiac function assessed by 6 min walking test distance(6MWD),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDd)and left ventricular posterior wall thickness(LVPWT),levles of inflammatory factors,including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and monocyte chemoattractant protein-1(MCP-1),and drug safety were compared between the two groups.ResultsAfter intervention,the blood lipid levels in the two groups were better than those before intervention,and the levels of TC,TG and LDL-C in the observation group were lower than those in the control group,and the level of HDL-C was higher than that in the control group(P<0.05).After intervention,the cardiac function indexes of the two groups were better than those before intervention,while the LVPWT and LVEDd of the observation group were lower than those of the control group,moreover,the 6MWD and LVEF were higher than those of the control group(P<0.05).After intervention,the levels of inflammatory factors in the two groups were lower than those before intervention,a

关 键 词：曲美他嗪 阿托伐他汀 冠心病 不稳定型心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]