预防周围神经粘连的研究进展  

Research progress on prevention of peripheral nerve adhesions

作　　者：仇一然 黄东旭(综述)[1] 宫旭(审阅)[1] Qiu Yiran;Huang Dongxu;Gong Xu(Department of Hand and Foot Surgery,Orthopaedics Centre,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院骨科中心手足外科,长春130021

出　　处：《中华显微外科杂志》2025年第1期107-112,共6页Chinese Journal of Microsurgery

基　　金：吉林省卫生健康科技能力提升项目(2024A016)。

摘　　要：周围神经创伤或手术干预可导致创伤性瘢痕和粘连,阻碍神经再生,进而会导致患者出现功能障碍。广泛瘢痕和粘连可能会压迫神经,损害其基本的滑动能力,并可能导致神经和神经周围组织内的纤维化。因此,寻找有效抗粘连策略以防止瘢痕组织形成已成为临床需要解决的重要挑战。目前,有关周围神经粘连具体的形成机制尚不全面,可应用于临床预防周围神经粘连的方法较少。本文从药物、物理屏障、物理方法及联合多种方式共同作用方面概述不同类型预防粘连方式和策略的临床前研究结果及可能作用机制,同时通过临床病例对照数据,对已进行临床应用或临床试验的防粘连方式进行评价,进而揭示这些预防周围神经粘连的策略在未来临床应用的可能性。Trauma or surgical intervention in peripheral nerves can lead to traumatic nerve scarring and adhesions,which could hinder nerve regeneration and potentially cause functional impairment.Extensive scarring and adhesions may compress nerves,impair the essential gliding ability and result in fibrosis within the nerves and surrounding tissues.Therefore,searching for effective anti-adhesion strategies to prevent scar formation has become a significant clinical challenge.Currently,the mechanisms underlying the formation of peripheral nerve adhesions are not yet fully understood,and there are limited clinical methods available to prevent the adhesions.This review summarise the preclinical research findings and potential mechanisms of various anti-adhesion strategies,including pharmacological approaches,physical barriers,physical methods,and the combination of them.Additionally,clinical trials and case-control data are evaluated to assess the effectiveness of anti-adhesion strategies that have been applied in clinical settings,providing insights into the potential for future clinical applications of the strategies in prevention of peripheral nerve adhesions.

关 键 词：周围神经粘连 神经瘢痕 生物材料 药剂 周围神经损伤 周围神经病 

分 类 号：R651.3[医药卫生—外科学]