可降解镁基复合材料的制备及其在骨科领域的研究进展  

Preparation of Biodegradable Mg-Based Composites and Their Recent Advances in Orthopedic Applications

作　　者：欧阳思慧 佘加 陈先华[1,2] 潘复生[1,2] OUYANG Sihui;SHE Jia;CHEN Xianhua;PAN Fusheng(National Engineering Research Center for Magnesium Alloys,Chongqing University,Chongqing 400044,China;College of Materials Science and Engineering,Chongqing University,Chongqing 400044,China;Lanxi Magnesium Materials Research Institute,Lanxi 321100,China)

机构地区：[1]重庆大学国家镁合金材料工程技术研究中心,重庆400044 [2]重庆大学材料科学与工程学院,重庆400044 [3]兰溪镁材料研究院,兰溪321100

出　　处：《金属学报》2025年第3期455-474,共20页Acta Metallurgica Sinica

基　　金：国家杰出青年科学基金项目No.52225101;国家自然科学基金项目No.52301132;中央高校基本科研业务费项目No.2023CDJYXTD-002。

摘　　要：可降解镁基材料因与骨相匹配的弹性模量和优良的成骨性能,成为21世纪极具前景的骨科植入材料。本工作总结了镁基复合材料在骨修复中的应用现状和发展趋势。首先,介绍了镁基复合材料的制备工艺及其优/缺点,着重分析了增强体选择对力学性能和降解行为的影响,并阐述了镁基复合材料在骨折固定、骨缺损修复等领域所取得的临床前研究进展,证实了其生物活性和临床安全性。随后,讨论了镁基复合材料在降解过程中对干细胞成骨分化的影响及相关分子机制。最后,结合现有临床前研究成果,归纳了镁基复合材料在骨修复应用中面临的挑战,并对其未来发展方向进行展望。Biodegradable Mg-based materials have emerged as a promising class of orthopedic implants in the 21st century,owing to their excellent osteogenic properties and an elastic modulus similar to that of cortical bone.This review summarizes the current applications and development trends of Mgbased composites in bone repair.First,the fabrication methods of Mg-based composites,along with their advantages and disadvantages,are discussed.Second,the impact of reinforcement on the mechanical properties and degradation behavior of these composites is examined.Third,preclinical studies on the use of Mg-based composites in fracture fixation and bone defect repair are reviewed,confirming their bioactivity and clinical safety.Fourth,the effects of the degradation behavior of Mg-based composites on stem cell osteogenic differentiation and the related molecular mechanisms are explored.Finally,the challenges of applying Mg-based composites for bone repair based on existing preclinical studies are outlined,and potential future advancements are proposed.

关 键 词：骨科应用 镁基复合材料 增强体 降解行为 力学性能 

分 类 号：TG146.2[一般工业技术—材料科学与工程]