外泌体在糖尿病肾病肾小管间质纤维化中的作用机制  

The mechanism of exosomes in tubulointerstitial fibrosis of diabetes nephropathy

作　　者：仲昭静 郭兆安[2] ZHONG Zhaojing;GUO Zhaoan(First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China;Nephrology Department,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji'nan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250014 [2]山东中医药大学附属医院肾内科,济南250014

出　　处：《生命的化学》2025年第3期427-432,共6页Chemistry of Life

基　　金：山东省自然科学基金项目(ZR2022LZY005)。

摘　　要：糖尿病肾病(diabetic nephropathy,DN)是导致终末期肾病的关键因素之一,具有进展快、病情重、并发症多等特点。肾小管间质纤维化(tubulointerstitial fibrosis,TIF)是导致DN进展至终末期肾病的核心环节,可通过多种途径加速DN的进展。目前临床上对于DN-TIF尚无特异性的诊疗措施,而外泌体的发现则为阻止甚至逆转这一过程提供了新的目标和方向。本文详细综述了不同类型的外泌体在DN-TIF中发挥的不同作用,以期为今后阻断DN-TIF提供新的诊疗思路。Diabetic nephropathy(DN)is one of the key factors leading to end-stage renal disease,characterized by rapid progression,severe clinical manifestations,and multiple complications.Tubulointerstitial fibrosis(TIF),as a recognized critical process leading to the progression of DN to end-stage renal disease,accelerates the progression of DN through various pathways.At present,there are no specific diagnostic and therapeutic measures for DN-TIF in clinical practice,and the discovery of exosomes provides new targets and directions for preventing or even reversing this process.This review comprehensively summarizes the diverse roles of different types of exosomes in DN-TIF,aiming to provide novel insights and therapeutic strategies for blocking DN-TIF progression.

关 键 词：糖尿病肾病 外泌体 肾小管间质纤维化 干细胞 

分 类 号：R587.2[医药卫生—内分泌]