中药靶向铁死亡治疗呼吸系统疾病的作用机制  

The mechanism of traditional Chinese medicine targeting ferroptosis for the treatment of pulmonary diseases

作　　者：叶敏 郭秀英 王丹心[4] 何光亮 YE Min;GUO Xiuying;WANG Danxin;HE Guangliang(International School of Nursing,Hainan Vocational University of Science and Technology,Haikou 571126,China;International School of Nursing,Hainan Medical University,Haikou 570100,China;Department of Respiratory Medicine,Hejiang County Traditional Chinese Medicine Hospital,Luzhou 646200,China;Nursing Department of the First Affiliated Hospital of Hainan Medical University,Haikou 571199,China)

机构地区：[1]海南科技职业大学国际护理学院,海口571126 [2]海南医科大学国际护理学院,海口570100 [3]合江县中医医院呼吸内科,泸州646200 [4]海南医学院第一附属医院护理部,海口571199

出　　处：《生命的化学》2025年第3期440-449,共10页Chemistry of Life

基　　金：海南省自然科学基金项目(823RC580);海南省高等学校科学研究项目(Hnky2021ZD-15)。

摘　　要：铁死亡作为一种新型的细胞死亡模态,以铁、脂质过氧化物以及活性氧(reactive oxygen species,ROS)的蓄积为典型特征,在呼吸系统疾病的治疗领域展现出极具潜力的双重价值。大量研究表明,抑制正常细胞的铁死亡可能有助于改善疾病及预后状况;诱导癌细胞发生铁死亡或能有效遏制癌细胞的增殖与迁移进程,进而减轻肿瘤进展态势。本综述聚焦中药(traditional Chinese medicine,TCM)对铁死亡的调控作用,系统梳理其借助多个靶点及多样化途径调节铁死亡的内在分子机制,旨在为呼吸系统疾病的预防与治疗挖掘潜在且行之有效的路径。此外,着重阐述了数种颇具应用潜力的中药化合物,此类化合物能够靶向作用于铁死亡相关过程、发挥延缓疾病进展之功效,以期为呼吸系统疾病临床防治策略的制定提供极具参考价值的依据。Ferroptosis,a novel form of cell death characterized by the accumulation of iron,lipid peroxides,and reactive oxygen species(ROS),plays a dual role in the treatment of respiratory diseases.Specifically,the inhibition of ferroptosis in normal cells may improve disease outcomes,while the inducing of ferroptosis in cancer cells can effectively suppress their proliferation and migration,thereby mitigating tumor progression.This review focuses on the regulatory role of traditional Chinese medicine(TCM)in ferroptosis.It systematically explores the molecular mechanisms by which TCM modulates ferroptosis through multiple targets and diverse pathways,aiming to identify potential and effective strategies for the prevention and treatment of respiratory diseases.Additionally,it highlights several TCM compounds with significant application potential.These compounds target ferroptosis to delay disease progression,offering valuable insights for the development of clinical prevention and treatment strategies for respiratory system diseases.

关 键 词：中药 铁死亡 呼吸系统疾病 预防和治疗 

分 类 号：R285[医药卫生—中药学]