基于尿酸转运蛋白探讨中药黄酮类成分治疗高尿酸血症的作用机制  

The mechanism of traditional Chinese medicine flavonoids in treating hyperuricemia based on uric acid transporters

作　　者：刘晓禹 范姝媛 白奉轩 王宇[1] 于栋华[1] 柳长凤[1] LIU Xiaoyu;FAN Shuyuan;BAI Fengxuan;WANG Yu;YU Donghua;LIU Changfeng(Institute of Traditional Chinese Medicine,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学中医药研究院,哈尔滨150040

出　　处：《生命的化学》2025年第3期480-488,共9页Chemistry of Life

基　　金：国家自然科学基金青年科学基金项目(81803871)。

摘　　要：随着社会的快速发展以及人们饮食习惯的改变,高尿酸血症(hyperuricemia,HUA)的发病率逐年攀升。尿酸排泄不足是HUA的主要诱因,中医药能够通过调控尿酸重吸收相关蛋白(URAT1、GLUT9、OAT4、OAT10)、尿酸分泌相关蛋白(ABCG2、OAT1、OAT2、OAT3、MRP4、NPT1、NPT4)等蛋白质降低尿酸水平,从而缓解HUA。本文系统综述了中药黄酮类化合物对HUA相关转运蛋白的调控作用,以期为黄酮类化合物防治HUA的机制研究、药物研发与临床应用提供理论依据。With the rapid development of society and changes in dietary habits,the incidence of hyperuricemia(HUA)is increasing year by year.Insufficient uric acid excretion is a primary factor contributing to HUA.Traditional Chinese medicine reduces uric acid levels by modulating uric acid reabsorption-related proteins(URAT1,GLUT9,OAT4,OAT10),uric acid secretion-related proteins(ABCG2,OAT1,OAT2,OAT3,MRP4,NPT1,NPT4)and other proteins,thereby alleviating HUA.This paper systematically reviews the research on the improvement of HUA related transporters of flavonoids in traditional Chinese medicine,aiming to provide theoretical support for the mechanism research,drug development and clinical application of flavonoids in the prevention and treatment of HUA.

关 键 词：高尿酸血症 尿酸转运蛋白 中医药 

分 类 号：R285[医药卫生—中药学]