结直肠癌类器官在中药及其有效成分研究中的应用进展  

Advancements in the utilization of colorectal cancer organoids for investigating traditional Chinese medicine and its bioactive constituents

作　　者：陈颖 王一[2] 王璐[3] 孔德松[3] 章阳[2] 樊志敏[3] Ying Chen;Yi Wang;Lu Wang;Desong Kong;Yang Zhang;Zhimin Fan(Department of Health Policy Research,Jiangsu Health Development Research Center,Nanjing 210036,China;Colon and Rectal Surgery,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China;Jiangsu Clinical Innovation Center for Anorectal Diseases of TCM,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China)

机构地区：[1]江苏省卫生健康发展研究中心卫生健康政策研究部,南京210036 [2]南京中医药大学附属南京中医院肛肠中心,210022 [3]南京中医药大学附属南京中医院江苏省中医肛肠疾病临床医学创新中心,210022

出　　处：《中华结直肠疾病电子杂志》2025年第1期47-52,共6页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：江苏省卫生健康发展研究中心2021年度开放课题(No.JSHD2021024);国家自然科学基金青年项目(No.82205024);江苏省重点研发计划(社会发展)项目(No.BE2021611);南京市中医药青年人才培养项目(No.NJSZYYQNRC-2020-WY2-2020)。

摘　　要：中药及其有效成分抗结直肠癌作用机制的研究主要依赖于体外结直肠癌细胞系以及相关移植瘤动物模型,而类器官技术已经成为了一种强大的替代方法,能够个性化还原供体的遗传特征,预测个体患者的疗效。在此,我们回顾了目前结直肠癌类器官在中药及其有效成分研究中应用的相关文献,评价了其在中医药基础研究中的独特价值,以期为中医药在结直肠癌中的更广泛临床应用提供更高级别的理论依据。The investigation into the mechanism of action of traditional Chinese medicine and its bioactive components against colorectal cancer primarily relies on in vitro colorectal cancer cell lines and related xenograft animal models.However,organoid has emerged as a potent alternative method that can faithfully recapitulate the genetic characteristics of donors and predict treatment efficacy for individual patients.In this review,we summarize the current literature on the application of colorectal cancer organoids in traditional Chinese medicine research,highlighting their unique value in advancing basic research and providing a solid theoretical foundation for broader clinical implementation of traditional Chinese medicine in treating colorectal cancer.

关 键 词：结直肠肿瘤 类器官 中医药 综述 

分 类 号：R285[医药卫生—中药学]