血清白细胞介素-6水平与糖尿病足患者感染严重程度的相关性研究  

Correlation between the level of serum IL-6 and the severity of infection in patients with diabetic foot

作　　者：李俊毅 熊亮 王鹏云 马清峰 Li Junyi;Xiong Liang;Wang Pengyun;Ma Qingfeng(Department of Clinical Laboratory,Liyuan Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院检验科,武汉430077

出　　处：《中华预防医学杂志》2025年第3期352-358,共7页Chinese Journal of Preventive Medicine

基　　金：湖北省自然科学基金(2023AFB848);华中科技大学同济医学院附属梨园医院院内科学研究资金资助(2023LYYYCXTD0001、2024LYYYGZRP0002)。

摘　　要：本研究探讨血清白细胞介素-6(interleukin-6,IL-6)水平与糖尿病足(diabetic foot,DF)患者感染严重程度的相关性以及IL-6在糖尿病足上的辅助诊断价值,以期为临床治疗提供参考。采用病例对照研究,根据医院病历系统和实验室系统,回顾性分析2020年1月至2024年9月就诊于华中科技大学同济医学院附属梨园医院的患者资料。本研究共收集377例患者信息,其中对照组31例,男性17例,女性14例,年龄范围31~91岁、中位数年龄71岁;糖尿病(diabetic mellitus,DM)不伴糖尿病足(no-diabetic foot,NDF)组63例,男性43例,女性20例,年龄范围37~96岁、中位数年龄71岁;糖尿病伴糖尿病足(diabetic foot,DF)组283例,男性197例,女性86例,年龄范围36~96岁、中位数年龄67岁。根据感染严重性分类,将283例DF组患者分为轻度感染亚组(72例)、中度感染亚组(143例)和重度感染亚组(68例)。结果显示,本研究中3组在年龄与性别上的差异无统计学意义(F=1.795/χ^(2)=2.81,P>0.05)。非参数检验结果显示,3组患者的IL-6、C-反应蛋白(C-reactive protein,CRP),降钙素原(procalcitonin,PCT)、白细胞(white blood cell,WBC)和血糖(glucose,GLU)差异均有统计学意义(H=12.480、36.277、12.432、12.838、18.334,P<0.05)。两两比较显示,与对照组相比,NDF组的CRP、PCT和GLU的水平较高,差异具有统计学意义(H=20.259、20.118、20.056,P<0.05);DF组的IL-6、CRP、PCT和WBC的水平较高,差异具有统计学意义(H=14.934、14.933、14.829、14.934,P<0.05)。而NDF组与DF组之间的IL-6、CRP、PCT、WBC和GLU之间的差异无统计学意义(H=1.202、0.622、0.737、1.036、1.899,P>0.05)。在DF组内,3个感染亚组患者之间的IL-6、CRP、PCT、WBC和GLU差异具有统计学意义(H=111.789、237.066、74.683、83.203、15.328,P<0.05)。与轻度感染亚组相比,重度感染亚组的IL-6、CRP、PCT、WBC和GLU水平较高,差异具有统计学意义(H=11.174、15.136、8.657、8.348、3.698,P<0.05);中度感染亚组�To explore the correlation between the level of serum interleukin-6(IL-6)and the severity of infection in patients with diabetic foot(DF)and the auxiliary value of IL-6 in DF diagnosis,and aim to provide reference for clinical treatment.Based on the hospital medical record system and the laboratory system,a retrospective analysis with case-control study was conducted on the data of patients in Liyuan Hospital affiliated to Tongji Medical College,Huazhong University of Science and Technology from January 2020 to September 2024.A total of 377 patients′information was collected,including 31 cases in control group with 17 males and 14 females from 31 to 91 years old and a median age of 71,63 cases in NDF group with 43 males and 20 females from 37 to 96 years old,with a median age of 71,and 283 patients in DF group with 197 males and 86 females from 36 to 96 years,with a median age of 67.According to classification of infection severity,paints in the group of diabetes with DF were divided into mild infection subgroup(72 cases),moderate infection subgroup(143 cases)and severe infection subgroup(68 cases).The results showed that there were no statistically significant differences in age and gender among the three groups in the study(F=1.795/χ^(2)=2.81,P>0.05).The non parametric test results showed that there were statistically significant differences in IL-6,C-reactive protein(CRP),procalcitonin(PCT),white blood cell(WBC)and glucose(GLU)among the three groups of patients(H=12.480,36.277,12.432,12.838,18.334,P<0.05).The pairwise comparison results showed that compared with the control group,the NDF group had higher levels of CRP,PCT and GLU(H=20.259,20.118,20.056,P<0.05),and the levels of IL-6,CRP,PCT and WBC(H=14.934,14.933,14.829,14.934,P<0.05)were higher in the DF group.Both of the differences were statistically significant.But the difference of IL-6,CRP,PCT,WBC and GLU between the NDF and DF group was not statistically significant(H=1.202,0.622,0.737,1.036,1.899,P>0.05).In DF group,there were statistically signifi

关 键 词：糖尿病足 白细胞介素-6 严重程度 相关性 

分 类 号：R587.2[医药卫生—内分泌]