宽胸气雾剂联合单硝酸异山梨酯对冠心病稳定型心绞痛患者心绞痛发作情况及心功能的影响  

Effect of Kuanxiong aerosol combined with isosorbide mononitrate on angina attacks and cardiac function in patients with stable angina pectoris of coronary heart disease

作　　者：阳成俊 甘斌修 谢丽堃 YANG Chengjun;GAN Binxiu;XIE Likun(Department of Cardiovascular Medicine,Yichun Second People's Hospital,Yichun Jiangxi 336000,China)

机构地区：[1]宜春市第二人民医院心血管内科,江西宜春336000

出　　处：《天津药学》2025年第3期270-273,共4页Tianjin Pharmacy

摘　　要：目的探讨宽胸气雾剂联合单硝酸异山梨酯对冠心病稳定型心绞痛患者心绞痛发作情况及心功能的影响。方法选择宜春市第二人民医院2022年1月至2024年10月收治的90例冠心病稳定型心绞痛患者,以随机数字表法分成两组,各45例。对照组采取单硝酸异山梨治疗,观察组在此基础上采取宽胸气雾剂治疗。治疗12周后,对比两组心绞痛发作情况、心功能、血管内皮功能、不良反应。结果治疗前,两组心绞痛发作情况、心功能、血管内皮功能比较,差异无统计学意义(P>0.05)。治疗后,观察组心绞痛发作频率[(1.54±0.28)次/周]少于对照组[(3.66±1.02)次/周],差异有统计学意义(t=13.445,P<0.001);观察组心绞痛发作持续时间[(2.31±0.20)min/次]短于对照组[(5.22±0.28)min/次],差异有统计学意义(t=56.731,P<0.001);观察组左室射血分数(LVEF)为(50.11±3.31)%,血管内皮生长因子(VEGF)为(70.22±4.97)ng/L,一氧化氮(NO)为(69.61±4.04)μmol/L,均高于对照组的(44.94±2.27)%、(65.51±4.72)ng/L、(62.80±3.96)μmol/L,差异有统计学意义(t=8.641、4.610、8.075,P均<0.001);观察组左室收缩末期内径(LVESD)为(31.24±2.05)mm,左室舒张末期内径(LVEDD)为(49.05±2.12)mm,内皮素1(ET-1)为(45.67±3.73)ng/L,均低于对照组的(37.23±2.10)mm、(55.51±3.14)mm、(51.49±4.25)ng/L,差异有统计学意义(t=13.692、11.438、6.904,P均<0.05)。观察组不良反应总发生率为15.56%(7/45),对照组为6.67%(3/45),两组差异无统计学意义(χ^(2)=1.800,P=0.180)。结论冠心病稳定型心绞痛患者联合应用宽胸气雾剂、单硝酸异山梨酯,可改善血管内皮功能,提升心功能,减少心绞痛发作情况,且安全性良好。Objective To investigate the effect of Kuanxiong aerosol combined with isosorbide mononitrate on angina attacks and cardiac function in patients with stable angina pectoris of coronary heart disease.Methods A total of 90 patients with stable angina pectoris of coronary heart disease were admitted to Yichun Second People's Hospital from January 2022 to October 2024.They were randomly divided into two groups using a random number table,with 45 patients in each group.The control group was treated with isosorbide mononitrate,and on this basis,the observation group was treated with Kuanxiong aerosol.The angina attacks,cardiac function,endothelial function,and adverse reactions in both groups were compared after 12 weeks of treatment.Results The comparisons of angina attacks,cardiac function,and vascular endothelial function in both groups before treatment showed no statistical difference(P>0.05);The observation group had lower frequency of angina attacks[(1.54±0.28)times/week]than the control group[(3.66±1.02)times/week]after treatment(t=13.445,P<0.001);The duration of angina attacks in the observation group was(2.31±0.20)min/episode,which was shorter than(5.22±0.28)min/episode in the control group(t=56.731,P<0.001);The left ventricular ejection fraction(LVEF)in the observation group was(50.11±3.31)%,vascular endothelial growth factor(VEGF)was(70.22±4.97)ng/L,and nitric oxide(NO)was(69.61±4.04)μmol/L,which were all higher than those in the control group[(44.94±2.27)%,(65.51±4.72)ng/L,and(62.80±3.96)μmol/L,respectively](t=8.641,4.610,8.075,all P<0.001);The left ventricular end-systolic diameter(LVESD)in the observation group was(31.24±2.05)mm,left ventricular end-diastolic diameter(LVEDD)was(49.05±2.12)mm,and endothelin-1(ET-1)was(45.67±3.73)ng/L,which were all lower than those in the control group[(37.23±2.10)mm,(55.51±3.14)mm,and(51.49±4.25)ng/L,respectively](t=13.692,11.438,6.904,all P<0.05);The total incidence of adverse reactions in the observation group[15.56%(7/45)]and control group[6.67%(3/45)

关 键 词：冠心病 稳定型心绞痛 宽胸气雾剂 单硝酸异山梨酯 心绞痛发作情况 心功能 

分 类 号：R532.3[医药卫生—内科学]