不同促性腺激素释放激素激动剂对行体外受精-胚胎移植患者妊娠结局的影响  

Effect of different gonadotropin-releasing hormone agonists on pregnancy outcomes in patients undergoing in vitro fertilization-embryo transfer

作　　者：苏丽霄[1] 张富青[1] 岳燕[1] 刘敏[1] 张静[1] SU Lixiao;ZHANG Fuqing;YUE Yan;LIU Min;ZHANG Jing(Department of Reproductive Genetics,Zhengzhou Maternal and Child Health Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市妇幼保健院生殖遗传科,河南郑州450000

出　　处：《天津药学》2025年第3期310-313,共4页Tianjin Pharmacy

摘　　要：目的探讨不同促性腺激素释放激素激动剂(GnRHa)对行体外受精-胚胎移植(IVF-ET)患者妊娠结局的影响。方法按随机数字表法将2022年10月至2024年10月郑州市妇幼保健院收治的82例行IVF-ET的不孕患者分为两组,各41例。对照组采用亮丙瑞林治疗,观察组采用曲普瑞林治疗。比较两组激素水平、促性腺激素(Gn)用量、用药天数、妊娠结局及不良反应。结果两组人绒毛膜促性腺激素(HCG)日雌二醇(E2)、促卵泡成熟素(FSH)水平均高于降调后20 d,且观察组治疗后HCG日E2水平为(3782.07±821.63)pmol/L,FSH水平为(14.96±2.63)U/L,均高于对照组的(3245.90±521.71)pmol/L、(13.32±1.85)U/L;两组HCG日促黄体生成素(LH)水平均低于降调后20 d,且观察组治疗后HCG日的LH水平为(1.63±0.68)U/L,低于对照组的(2.02±0.76)U/L(P<0.05)。观察组采用曲普瑞林治疗的Gn用量[(2108.55±267.42)U]低于对照组[(2476.25±312.19)U],胚胎种植率(65.79%)和临床妊娠率(65.85%)高于对照组(49.33%、41.46%)(P<0.05)。两组用药天数及不良反应比较,无统计学差异(P>0.05)。结论行IVF-ET患者采用曲普瑞林治疗效果优于亮丙瑞林,利于调节患者激素水平,提高胚胎种植率和临床妊娠率,改善患者妊娠结局,且不良反应较少,临床应用安全可靠。Objective To investigate the effect of different gonadotropin-releasing hormone agonists(GnRHa)on pregnancy outcomes in patients undergoing in vitro fertilization-embryo transfer(IVF-ET).Methods A total of 82 infertile patients undergoing IVF-ET treated in Zhengzhou Maternal and Child Health Hospital from October 2022 to October 2024 were randomly divided into two groups according to a random number table,with 41 patients in each group.The control group was treated with leuprorelin,while the observation group was treated with triptorelin.The hormone levels,gonadotropin(Gn)dosage,medication days,pregnancy outcomes,and adverse reactions were compared between the two groups.Results The levels of estradiol(E2)and follicle-stimulating hormone(FSH)on the day of human chorionic gonadotropin(HCG)administration were higher in both groups compared to those 20 days after down-regulation.In the observation group,the E2 level[(3782.07±821.63)pmol/L]and FSH level[(14.96±2.63)U/L]on the day of HCG administration were higher than those in the control group[(3245.90±521.71)pmol/L and(13.32±1.85)U/L,respectively].The luteinizing hormone(LH)levels on the day of HCG administration in both groups were lower than those 20 days after down-regulation,and the LH level in the observation group[(1.63±0.68)U/L]was lower than that in the control group[(2.02±0.76)U/L](P<0.05).The gonadotropin(Gn)dosage in the observation group treated with triptorelin[(2108.55±267.42)U]was lower than that in the control group[(2476.25±312.19)U].Additionally,the embryo implantation rate(65.79%)and clinical pregnancy rate(65.85%)in the observation group were higher than those in the control group(49.33%and 41.46%,respectively)(P<0.05).There were no statistically significant differences in the duration of medication or adverse reactions between the two groups(P>0.05).Conclusion Triptorelin is more effective than leuprorelin in patients undergoing IVF-ET,as it helps regulate hormone levels,improve embryo implantation rates and clinical pregnancy rates,and

关 键 词：不孕 体外受精-胚胎移植 曲普瑞林 亮丙瑞林 妊娠结局 激素水平 

分 类 号：R711.6[医药卫生—妇产科学]