阿奇霉素联合干扰素雾化治疗儿童类百日咳综合征的临床疗效及安全性  

Clinical Efficacy and Safety of Azithromycin Combined with Interferon Nebulization in the Treatment of Pertussis-like Syndrome in Children

作　　者：孙志华 陈瑞 王凤圈 于泓泽 黄永霞 SUN Zhi-hua;CHEN Rui;WANG Feng-quan;YU Hong-ze;HUANG Yong-xia(Department of Pediatric Intensive Medicine,Zhumadian Central Hospital,Zhumadian 463000,China;Department of Emergency Pediatrics,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院儿童重症医学科,驻马店463000 [2]驻马店市中心医院急诊儿科,驻马店463000

出　　处：《中国合理用药探索》2025年第3期82-86,共5页Chinese Journal of Rational Drug Use

摘　　要：目的:分析阿奇霉素联合干扰素雾化治疗儿童类百日咳综合征(PLS)的临床疗效及安全性。方法:选取2021年10月~2022年2月就诊于某院的PLS患儿80例,随机编号将其分为观察组和对照组,观察组采用阿奇霉素联合干扰素雾化治疗,对照组单用干扰素雾化治疗,分别比较患儿的临床疗效及血清学指标,并观察两组患儿是否出现不良反应。结果:治疗后,两组患儿痉挛性咳嗽持续时间、肺部啰音消失时间、住院总时长比较具有统计学差异(P<0.05);颜面憋红次数、血清学指标间比较无统计学差异(P>0.05);两组患儿均未出现不良反应。结论:阿奇霉素联合干扰素雾化治疗PLS不仅可以改善患儿的主要临床症状,如缩短痉挛性咳嗽持续时间和肺部啰音消失时间,还可以减少住院总时长,从而降低患儿的痛苦和家庭的经济负担,具有重要的临床应用价值。Objective:To analyze the clinical efficacy and safety of azithromycin combined with interferon nebulization in the treatment of children with pertussis-like syndrome(PLS).Methods:Eighty children with PLS visiting the hospital from October 2021 to February 2022 were randomly divided into an observation group and a control group.The observation group was treated with azithromycin combined with interferon nebulization,while the control group was treated with interferon nebulization alone.The clinical efficacy and serological indexes were compared between the two groups.The adverse reactions were observed.Results:After treatment,there were significant differences in the duration of spastic cough,time to disappearance of pulmonary rales and the total length of hospital stay between the two groups(P<0.05).There was no significant difference in the frequency of reddening of the face,general data and serological indexes(P>0.05);there were no adverse reactions in the two groups.Conclusion:Azithromycin combined with interferon nebulization therapy for PLS not only significantly improved the main clinical symptoms of children,such as shortening the duration of spasmodic cough and disappearance of pulmonary rales,but also reduced the total length of hospital stay,thereby reducing the pain of children and the economic burden on families,and has important clinical application value.

关 键 词：阿奇霉素 干扰素雾化 儿童 百日咳 临床疗效 安全性 

分 类 号：R725.1[医药卫生—儿科]