滋肾护肝方治疗肝肾阴虚证卵巢早衰的临床研究  

Clinical Study on Zishen Hugan Formula in the Treatment of Premature Ovarian Failure with Liver-Kidney Yin Deficiency Syndrome

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作  者:任亚萍 冯理想 郭晓莉 REN Ya-ping;FENG Li-xiang;GUO Xiao-li(Department of Obstetrics and Gynecology,Xuchang Hospital of Traditional Chinese Medicine,Xuchang 461000,China)

机构地区:[1]许昌中医院妇产科,许昌461000

出  处:《中国合理用药探索》2025年第3期126-131,共6页Chinese Journal of Rational Drug Use

摘  要:目的:探讨滋肾护肝方治疗肝肾阴虚证卵巢早衰患者的临床应用效果。方法:前瞻性选取2020年10月~2022年10月期间某院收治的90例肝肾阴虚证卵巢早衰患者作为研究对象,采用随机数字表法分为对照组和观察组,每组45例。对照组患者给予雌二醇片/雌二醇地屈孕酮片复合包装治疗,观察组患者给予滋肾护肝方治疗,两组均治疗3个疗程。比较两组患者性激素[卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E_(2))]水平、临床疗效、不良反应发生情况及随访6个月的疾病复发情况。结果:治疗3个疗程后,两组患者血清FSH和LH水平均降低(P<0.05),且观察组低于对照组(P<0.05);血清E_(2)水平均升高(P<0.05),且观察组高于对照组(P<0.05);观察组患者治疗总有效率(95.56%)高于对照组(80.00%,P<0.05);观察组患者不良反应总发生率(4.44%)低于对照组(17.78%,χ^(2)=4.050,P=0.044)。随访6个月,观察组患者复发率(2.22%)低于对照组(17.78%,χ^(2)=4.444,P=0.035)。结论:滋肾护肝方可提高肝肾阴虚证卵巢早衰患者的临床疗效,改善患者雌激素水平,且不良反应较少、复发率低。Objective:To investigate the clinical efficacy of Zishen Hugan formula in the treatment of patients with premature ovarian failure and liver-kidney yin deficiency syndrome.Methods:A total of 90 patients with premature ovarian failure and liver-kidney yin deficiency syndrome treated in a hospital from October 2020 to October 2022 were selected prospectively and assigned to the control group and the observation group by random number table method,with 45 patients in each group.The control group was treated with complex packing estradiol tablets/estradiol and dydrogesterone tablets,and the observation group was treated with Zishen Hugan formula.Both groups were treated for 3 courses.The levels of sex hormones[follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))],clinical efficacy,adverse reactions and disease recurrence after 6-month follow-up were compared between the two groups.Results:After 3 courses of treatment,the levels of serum FSH and LH were decreased in both groups(P<0.05),with the observation group showing lower levels than the control group(P<0.05).The serum E_(2) level was increased in both groups(P<0.05),with the observation group showing higher levels than the control group(P<0.05).The total effective rate in the observation group(95.56%)was higher than that in the control group(80.00%,P<0.05).The total incidence of adverse reactions in the observation group(4.44%)was lower than that in the control group(17.78%,χ^(2)=4.050,P=0.044).After 6-month follow-up,the recurrence rate in the observation group(2.22%)was lower than that in the control group(17.78%,χ^(2)=4.444,P=0.035).Conclusion:Zishen Hugan formula can improve the clinical efficacy in patients with premature ovarian failure and liver-kidney yin deficiency syndrome,improving estrogen levels,with fewer adverse reactions and a lower recurrence rate.

关 键 词:卵巢早衰 肝肾阴虚证 滋肾护肝方 雌激素 临床疗效 性激素 

分 类 号:R271.1[医药卫生—中医妇科学]

 

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