妊娠糖尿病患者血清白脂素的表达及其与糖脂代谢的相关性研究  

Expression of serum asprosin in patients with gestational diabetes mellitus and its correlation with glucose and lipid metabolism

作　　者：李思曼 陈娟 张文杰 LI Siman;CHEN Juan;ZHANG Wenjie(Department of Women's Health Care,Northwest Women and Children's Hospital,Xi'an,Shaanxi 710061,China;不详)

机构地区：[1]西北妇女儿童医院妇女保健科,陕西西安710061 [2]咸阳市第一人民医院产科,陕西咸阳712000

出　　处：《中华全科医学》2025年第3期362-364,429,共4页Chinese Journal of General Practice

基　　金：陕西省重点研发计划项目(2022SF-277)。

摘　　要：目的探讨妊娠糖尿病(GDM)患者血清白脂素是否存在异常表达,并分析其与糖脂代谢指标的关系,为分析GDM的发病机制提供新思路。方法选取2020年4月-2021年4月西北妇女儿童医院收治的86例GDM患者(GDM组)和50例健康孕妇(对照组)。GDM患者根据血清白脂素中位数水平分为高表达组(44例)和低表达组(42例)。检测糖脂代谢指标和白脂素水平,分析白脂素与其他指标的相关性,采用多因素logistic回归分析研究GDM的危险因素。结果GDM组血清白脂素水平[(2.56±0.61)ng/mL]高于对照组[(1.12±0.43)ng/mL,P<0.05]。GDM患者血清白脂素与三酰甘油、总胆固醇、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)均呈正相关关系(r=0.312、0.327、0.403、0.462、0.518,均P<0.05)。多因素logistic回归分析显示,FBG(OR=3.216,95%CI:1.434~7.210)、FINS(OR=2.869,95%CI:1.395~5.902)、HOMA-IR(OR=3.511,95%CI:1.456~8.466)、白脂素(OR=2.659,95%CI:1.295~7.003)水平过高均是GDM的危险因素(P<0.05)。结论GDM患者血清白脂素呈高表达,且与患者糖脂代谢水平密切相关。Objective To investigate whether there is abnormal expression of serum asprosin in patients with gestational diabetes mellitus(GDM),and to analyze its relationship with glycolipid metabolism indexes,so as to provide new ideas for the pathogenesis of GDM.Methods A total of 86 GDM patients(GDM group)and 50 healthy pregnant women(control group)were selected from Northwest Women and Children's Hospital from April 2020 to April 2021.GDM patients were divided into a high-expression group(n=44)and a low-expression group(n=42).Glucose and lipid metabolism indexes and serum asprosin level were detected,the correlation between serum asprosin and other indexes was analyzed,and the risk factors of GDM were analyzed by multi-factor logistic regression.Results The level of serum asprosin in the GDM group[(2.56±0.61)ng/mL]was higher than that in the control group[(1.12±0.43)ng/mL,P<0.05].Serum asprosin were positively correlated with triacylglycerol,total cholesterol,fasting blood glucose(FBG),fasting insulin(FINS),and insulin resistance index(HOMA-IR)in GDM patients(r=0.312,0.327,0.403,0.462,0.518,all P<0.05).High levels of FBG(OR=3.216,95%CI:1.434-7.210),FINS(OR=2.869,95%CI:1.395-5.902),HOMA-IR(OR=3.511,95%CI:1.456-8.466),serum asprosin(OR=2.659,95%CI:1.295-7.003)were risk factors for GDM(P<0.05).Conclusion The high expression of serum asprosin in patients with GDM is closely related to the level of glucose and lipid metabolism.

关 键 词：妊娠糖尿病 白脂素 胰岛素抵抗 脂代谢 糖代谢 

分 类 号：R714.256[医药卫生—妇产科学]