子痫前期孕妇血清维生素D水平对新生儿结局的影响  

Effects of serum vitamin D levels on neonatal outcomes in pregnant women with preeclampsia

作　　者：肖佳荔 罗晶 江余明[1] 曹芳 张寅英[1] 杨戎威 XIAO Jiali;LUO Jing;JIANG Yuming;CAO Fang;ZHANG Yinying;YANG Rongwei(Neonatal Department,Jiaxing Maternal and Child Health Hospital,Jiaxing,Zhejiang 314000,China)

机构地区：[1]嘉兴市妇幼保健院新生儿科,浙江嘉兴314000

出　　处：《中华全科医学》2025年第3期439-442,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2023KY1218)。

摘　　要：目的子痫前期(PE)孕妇不良妊娠结局风险升高,本研究旨在分析血清维生素D(VD)缺乏的严重程度与胎龄、新生儿出生体重及新生儿不良结局的关系,为降低PE孕妇不良妊娠结局提供新思路。方法选择2023年1月-2023年12月嘉兴市妇幼保健院诊治的PE患者280例作为PE组、正常孕妇280例作为对照组,比较PE患者与对照组血清25(OH)D水平的差异。在PE患者中,按照血清25(OH)D水平分为VD严重缺乏组、VD轻度缺乏组、VD正常组。应用二分类logistic回归方程分析患者血清VD缺乏与不良妊娠结局间的相关性。结果PE组孕妇血清25(OH)D水平[(48.29±12.88)nmol/L]显著低于对照组[(57.75±11.92)nmol/L],差异有统计学意义(P<0.05)。VD严重缺乏组重度PE发生率显著高于VD正常组及VD轻度缺乏组(P<0.05),而VD正常组与VD轻度缺乏组比较差异无统计学意义(P>0.05);VD严重缺乏组胎龄、新生儿出生体重、Apgar评分均低于VD正常组及VD轻度缺乏组,新生儿窒息发生率高于VD正常组及VD轻度缺乏组,差异有统计学意义(P<0.05),而VD正常组及VD轻度缺乏组比较差异无统计学意义(P>0.05);3组围产儿死亡率比较差异无统计学意义(P>0.05);多因素logistic回归分析显示,患者年龄>35岁、BMI>25、重度PE、VD严重缺乏是新生儿不良结局的独立危险因素。结论在PE患者中,血清VD严重缺乏会增加新生儿不良结局的风险。Objective Pregnant women with preeclampsia(PE)have an increased risk of adverse pregnancy outcomes.This study analyzed the relationship between the severity of serum vitamin D(VD)deficiency and gestational age,newborn birth weight,and neonatal adverse outcomes,and provided new ideas for reducing adverse pregnancy outcomes in women with PE.Methods A total of 280 PE patients treated in Jiaxing Maternal and Child Health Hospital from January 2023 to December 2023 were selected as the PE group and 280 normal pregnant women as the control group,and the difference of serum 25(OH)D level between PE patients and control group was compared.PE patients were divided into severe VD deficiency group,mild VD deficiency group,and normal VD group according to serum 25(OH)D level.The binary logistic regression equation was used to investigate the relationship between serum VD deficiency and adverse pregnancy outcomes.Results The serum 25(OH)D level in the PE group[(48.29±12.88)nmol/L]was significantly lower than that in the control group[(57.75±11.92)nmol/L],and the difference was statistically significant(P<0.05).The incidence of severe PE in the severe VD deficiency group was significantly higher than that in the normal VD group and the mild VD deficiency group(P<0.05),but there was no statistical significance between the normal VD group and the mild VD deficiency group(P>0.05).Gestational age,neonatal birth weight,and Apgar score in severe VD deficiency group were lower than those in normal VD group and mild VD deficiency group,and the incidence of neonatal asphyxia was higher than that in normal VD group and mild VD deficiency group,with statistical significance(P<0.05),while there was no statistical significance between normal VD group and mild VD deficiency group(P>0.05).There was no significant difference in perinatal mortality among the three groups(P>0.05).Multivariate logistic regression results showed that age>35 years old,BMI>25,severe PE,and VD deficiency were independent risk factors for neonatal adverse outcomes.

关 键 词：子痫前期 维生素D 新生儿 妊娠 

分 类 号：R714.246[医药卫生—妇产科学]