不同年龄分层下儿童维生素D和维生素K_(1)、K_(2)水平分析  

Analysis of vitamin D and vitamin K_(1),K_(2)levels in children under different age stratifications

作　　者：莫杰恋 陈樱君[1] 方秀业 MO Jielian;CHEN Yingjun;FANG Xiuye(Laboratory Department,the Second People's Hospital of Qinzhou,Qinzhou 535000,China)

机构地区：[1]钦州市第二人民医院检验科,广西钦州535000

出　　处：《临床医学研究与实践》2025年第10期30-33,共4页Clinical Research and Practice

基　　金：国家卫生健康委医药卫生科技发展研究中心课题(No.WA2020HK36)。

摘　　要：目的分析不同年龄分层下儿童维生素D和维生素K_(1)、K_(2)水平。方法收集2020年8月至2023年12月在钦州市第二人民医院儿科行体格检查的296名儿童的临床资料,根据年龄将其分为0~1岁、>1~3岁、>3~6岁、>6~12岁、>12岁。比较不同年龄分层下儿童的维生素D和维生素K_(1)、K_(2)水平及分布状况;分析这三种维生素与年龄之间的相关性。结果维生素D、K_(1)水平随年龄增长呈下降趋势,其中0~1岁儿童的维生素D、K_(1)水平均显著高于其他年龄层,且过量占比均显著高于>3~6岁、>6~12岁的儿童(P<0.05);>3~6岁的儿童维生素K_(2)缺乏的占比高于0~1岁、>1~3岁和>6~12岁的儿童(P<0.05)。Spearman相关分析结果显示,维生素D、K_(1)与年龄均呈中等强度的负相关(P<0.001);维生素K_(2)与年龄无显著相关性(P>0.05)。结论钦州地区0~15岁儿童维生素D、K_(1)总体水平良好,低龄儿童存在过量风险,学龄期易缺乏;维生素K_(2)缺乏情况较为普遍。临床医生应重视儿童维生素的定期检测,并根据年龄差异指导合理补充。Objective To analyze the levels of vitamin D and vitamin K_(1)and K_(2)in children under different age stratifications.Methods The clinical data of 296 children who underwent physical examination in the pediatrics department of the Second People's Hospital of Qinzhou from August 2020 to December 2023 were collected.According to age,the children were divided into 0-1 years old,>1-3 years old,>3-6 years old,>6-12 years old and>12 years old.The levels and distribution of vitamin D,vitamin K_(1)and K_(2)in children under different age stratifications were compared;and the correlation between these three vitamins and age was analyzed.Results The levels of vitamin D and K_(1)decreased with age,the levels of vitamin D and K_(1)in children aged 0-1 years old were significantly higher than those in other age groups,and the proportion of excess was significantly higher than that in children aged>3-6 years old and>6-12 years old(P<0.05);the proportion of vitamin K_(2)deficiency in children aged>3-6 years old was more than that in children aged 0-1 years old,>1-3 years old and>6-12 years old(P<0.05).Spearman correlation analysis results showed that vitamin D and K_(1)were negatively correlated with age(P<0.001);there was no significant correlation between vitamin K_(2)and age(P>0.05).Conclusion The overall levels of vitamin D and K_(1)in children aged 0-15 years in Qinzhou area are good,and there is a risk of excess in lower age children,and school-age children are prone to lack;vitamin K_(2)deficiency is common.Clinicians should pay attention to the regular detection of vitamins in children and guide reasonable supplementation according to age differences.

关 键 词：维生素D 维生素K_(1) 维生素K_(2) 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健]