低出生体重与足出生体重新生儿化脓性脑膜炎的临床分析  

Clinical analysis of purulent meningitis in low birth weight and normal birth weight neonates

作　　者：凌远连 卢燕彬 刘小琳 周海燕[1] 吴耀勋[1] LING Yuanlian;LU Yanbin;LIU Xiaolin;ZHOU Haiyan;WU Yaoxun(Yulin Maternal and Child Health Care Hospital,Yulin 537000,China)

机构地区：[1]玉林市妇幼保健院,广西玉林537000

出　　处：《临床医学研究与实践》2025年第10期42-45,共4页Clinical Research and Practice

基　　金：广西壮族自治区卫生健康委自筹经费科研课题(No.Z-K20231786);玉林市科学研究与技术开发计划项目(玉市科202235091)。

摘　　要：目的探讨低出生体重(LBW)与足出生体重(NBW)新生儿化脓性脑膜炎的临床表现、实验室检查及治疗转归等方面的差异,以期为临床提供更有效的诊疗策略。方法选取2021年1月至2023年12月玉林市妇幼保健院儿科收治的147例化脓性脑膜炎患儿作为研究对象,依据新生儿出生体重将其分为LBW组、NBW组。比较两组的一般资料、脑脊液和外周血指标、病原菌种类检测结果及治疗转归情况。结果147例化脓性脑膜炎患儿中,LBW组29例,NBW组118例。LBW组的胎龄、入院日龄小于NBW组,出生体重低于NBW组,住院天数长于NBW组(P<0.05)。LBW组的脑脊液中,葡萄糖水平低于NBW组,蛋白质水平和白细胞计数(WBC)高于NBW组(P<0.05);LBW组的外周血中,C反应蛋白(CRP)水平及WBC低于NBW组(P<0.05)。LBW组有2例脑脊液和7例外周血培养呈病原菌阳性,NBW组有14例脑脊液和19例外周血培养呈病原菌阳性。两组的治疗转归情况比较,差异无统计学意义(P>0.05)。结论LBW新生儿化脓性脑膜炎的临床表现以及脑脊液和外周血实验室检查结果更为复杂和严重。因此,在临床实践中,应给予LBW新生儿更密切的关注,通过早期识别、精准诊断、个体化治疗和多学科协作,降低化脓性脑膜炎的发病率和死亡率。Objective To explore the differences in clinical manifestations,laboratory examinations and treatment outcome between low birth weight(LBW)and normal birth weight(NBW)neonates purulent meningitis,in order to provide more effective diagnosis and treatment strategies for clinical practice.Methods A total of 147 children with purulent meningitis admitted in the pediatrics department of Yulin Maternal and Child Health Care Hospital from January 2021 to December 2023 were selected as the research objects.According to the birth weight of neonates,the children were divided into LBW group and NBW group.The general data,cerebrospinal fluid and peripheral blood indexes,positive test results of pathogenic bacteria and treatment outcome were compared between the two groups.Results Of 147 children with purulent meningitis,29 cases in the LBW group and 118 cases in the NBW group.The gestational age and admission age of the LBW group were less than those of the NBW group,the birth weight was lower than that of the NBW group,and the hospitalization day was longer than that of the NBW group(P<0.05).In the cerebrospinal fluid of the LBW group,the glucose level was lower than that in the NBW group,and the protein level and white blood cell count(WBC)were higher than those in the NBW group(P<0.05);in the peripheral blood of the LBW group,the C-reactive protein(CRP)level and WBC were lower than those in the NBW group(P<0.05).In the LBW group,2 cases of cerebrospinal fluid and 7 cases of peripheral blood culture were positive for pathogenic bacteria.In the NBW group,14 cases of cerebrospinal fluid and 19 cases of peripheral blood culture were positive for pathogenic bacteria.There was no significant difference in the treatment outcome between the two groups(P>0.05).Conclusion The clinical manifestations and the results of cerebrospinal fluid and peripheral blood laboratory tests are more complex and serious of purulent meningitis in LBW neonates.Therefore,in clinical practice,LBW neonates should be given closer attention to reduce the

关 键 词：低出生体重 足出生体重 化脓性脑膜炎 

分 类 号：R722[医药卫生—儿科]