S(+)-氯胺酮在围手术期镇痛中的研究进展  

Research progress of S(+)-ketamine in perioperative analgesia

作　　者：李鹏 曹天彪 LI Peng;CAO Tianbiao(Anesthesiology Department,Jiuquan Hospital,Shanghai General Hospital(the People's Hospital of Jiuquan),Jiuquan 735000,China)

机构地区：[1]上海市第一人民医院酒泉医院(酒泉市人民医院)麻醉科,甘肃酒泉735000

出　　处：《临床医学研究与实践》2025年第10期187-190,共4页Clinical Research and Practice

摘　　要：S(+)-氯胺酮辅助全身麻醉有助于提升术后镇痛效果,能够在术后短时间内降低疼痛强度并减少阿片类药物的需要量,但可能增加拟精神药物不良事件的发生率。围手术期应用S(+)-氯胺酮可减少阿片类药物的使用,为了降低潜在精神障碍等副作用的风险,S(+)-氯胺酮往往局限于小剂量方案。作为多模式围手术期疼痛管理的一个组成部分,即使是低剂量的S(+)-氯胺酮也已足够。本文主要讨论关于S(+)-氯胺酮在妇产科手术、胸科手术、脊柱手术、老年患者及小儿围手术期镇痛中的应用,旨在为临床提供更安全、有效的疼痛管理策略。S(+)-ketamine-assisted general anesthesia is helpful to improve postoperative analgesia,which can reduce pain intensity and opioid requirements in a short time after surgery,but may increase the incidence of adverse events of psychotropic drugs.Perioperative application of S(+)-ketamine can reduce the use of opioid.In order to reduce the risk of side effects such as potential mental disorders,S(+)-ketamine is often limited to low-dose regimens.As an integral part of multimodal perioperative pain management,even low doses of S(+)-ketamine are sufficient.This article mainly discusses the application of S(+)-ketamine in perioperative analgesia in gynecology and obstetrics surgery,thoracic surgery,spinal surgery,elderly patients and children,aiming to provide a safer and more effective pain management strategy for clinic.

关 键 词：S(+)-氯胺酮 围手术期 镇痛 

分 类 号：R971[医药卫生—药品]