基于生物信息学解析PLK1基因在肺腺癌中的预后价值和作用机制  

Prognostic value and function mechanism of PLK1 gene in lung adenocarcinoma based on bioinformatics analysis

作　　者：杨斯絮 于焱 郭桐宇 曹悦 于欣竺 张文迪 李宁 YANG Sixu;YU Yan;GUO Tongyu;CAO Yue;YU Xinzhu;ZHANG Wendi;LI Ning(Teaching and Research Office of Bioinformatics,Shenyang Medical College,Liaoning,Shenyang 110000,China;Teaching and Research Office of Pathology and Pathophysiology,Shenyang Medical College,Liaoning,Shenyang 110000,China;Teaching and Research Office of Biotechnology,Shenyang Medical College,Liaoning,Shenyang 110000,China;Key Laboratory of Human Population Specificity and Phenotype of Important Diseases in Liaoning Province,Liaoning,Shenyang 110000,China)

机构地区：[1]沈阳医学院生物信息学教研室,辽宁沈阳110000 [2]沈阳医学院病理学与病理生理学教研室,辽宁沈阳110000 [3]沈阳医学院生物技术教研室,辽宁沈阳110000 [4]辽宁省人类族群特异性及重要疾病表型组学重点实验室,辽宁沈阳110000

出　　处：《中国医药科学》2025年第6期4-7,共4页China Medicine And Pharmacy

基　　金：辽宁省大学生创新创业项目(202310164009);沈阳医学院大学生科研项目(20239003)。

摘　　要：目的 探讨Polo样激酶1(PLK1)基因在肺腺癌(LUAD)中的表达、临床价值及与LUAD发生、发展的关系。方法 GEO数据库中筛选LUAD的差异表达基因并根据相关性强度确定核心基因。利用Oncomine数据库分析核心基因在LUAD中的表达变化。Kaplan-Meier生存分析用于评估PLK1表达水平与总生存期(OS)的相关性;logsitic回归模型用于评价PLK1表达水平与不同临床病理学参数的相关性;Cox回归模型用于探讨影响LUAD患者生存的预后因素。结果 PLK1在LUAD中显著上调,并与临床分期、T期、N期、M期及性别显著相关;Kaplan-Meier分析及单变量Cox回归均显示,PLK1的高表达与OS相关,多变量分析确认其为独立预后因子。结论 PLK1可能是LUAD的一个潜在的独立预后因素。Objective To investigate the expression,clinical value,and relationship between Polo-like kinase 1(PLK1)gene and the occurrence and development of lung adenocarcinoma(LUAD).Methods Differentially expressed genes of LUAD selected from GEO database and core genes based on correlation strength were determined.The expression changes of core genes in LUAD were analyzed using the Oncomine database.Kaplan Meier survival analysis was used to evaluate the correlation between PLK1 expression levels and overall survival(OS).The logistic regression model was used to evaluate the correlation between PLK1 expression levels and different clinical pathological parameters.Cox regression model was used to investigate prognostic factors impacting the survival of patients with LUAD.Results PLK1 was significantly upregulated in LUAD and significantly correlated with clinical stage,T stage,N stage,M stage,and gender;Kaplan-Meier analysis and univariate Cox regression both showed that high expression of PLK1 was associated with OS,and multivariate analysis confirmed it as an independent prognostic factor.Conclusion PLK1 may be a potential independent prognostic factor for LUAD.

关 键 词：POLO样激酶1 肺腺癌 数据库 预后 生物信息学 

分 类 号：R318[医药卫生—生物医学工程] R754.2[医药卫生—基础医学]