川崎病儿童的肠道菌群变化情况分析  

Analysis on the changes of intestinal flora in children with Kawasaki disease

作　　者：史彤彤 安新江 王燕 许永茂 王飞 SHI Tongtong;AN Xinjiang;WANG Yan;XU Yongmao;WANG Fei(Department of Cardiovascular Internal Medicine,Xuzhou Children’s Hospital Affiliated to Xuzhou Medical University,Jiangsu,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属徐州儿童医院心血管内科,江苏徐州221000

出　　处：《中国医药科学》2025年第6期53-56,共4页China Medicine And Pharmacy

基　　金：江苏省重点实验室开放课题(XZSYSKF2021045)。

摘　　要：目的 针对川崎病儿童的肠道菌群变化情况展开分析与探讨。方法 选择2021年5月至2023年7月徐州医科大学附属徐州儿童医院收治的107例儿童为研究对象,包括50例川崎病儿童(观察组)和57例非川崎病儿童(对照组),针对两组肠道菌群检测情况进行比较与分析。结果 肠道菌群多样性对照结果方面,观察组基于丰度的覆盖度估计(Ace)指数高于对照组,差异有统计学意义(P <0.05);二者香农-威纳(Shannon)指数比较,差异无统计学意义(P> 0.05)。肠道菌群构成对照结果方面,从门水平角度,观察组厚壁菌门占比低于对照组,拟杆菌门高于对照组,差异有统计学意义(P <0.05);二者变形菌门占比比较,差异无统计学意义(P> 0.05);从属水平角度,观察组乳杆菌属、韦荣球菌属占比均低于对照组,拟杆菌属占比高于对照组,差异有统计学意义(P <0.05)。结论 川崎病儿童的肠道菌群情况同非川崎病儿童比较,具有显著性差别,前者往往存在肠道菌群紊乱问题,且容易进一步诱发冠状动脉病变,因此应当在临床诊治工作开展中予以高度关注。Objective To analyze and discuss the changes of intestinal flora in children with Kawasaki disease.Methods A total of 107 Children admitted to Xuzhou Children’s Hospital Affiliated to Xuzhou Medical University from May 2021 to July 2023 were selected as the study sudjects,and they were divided into the observation group(n=50,children with Kawasaki disease)and the control group(n=57,healthy children without Kawasaki disease).The detection situation of intestinal flora in the two groups was compared and analyzed.Results Compared with the control results of intestinal flora diversity,the abundance-based coverage estimator(Ace)index in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).Compared with Shannon-Wiener(Shannon)index,the difference was not statistically significant(P>0.05).In terms of comparison results of intestinal flora composition,from the point of view of phylum,the proportion of Firmicutes in the observation group was lower than that in the control group,and Bacteroides was higher than that in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the proportion of Proteobacteria between them(P>0.05).From the perspective of genus level,the proportion of Lactobacillus and Veyrococcus in the observation group was lower than that in the control group,and the proportion of Bacteroides was higher than that in the control group,with statistically significant differences(P<0.05).Conclusion The intestinal flora of children with Kawasaki disease is significantly different from that of children without Kawasaki disease.The former often has the problem of intestinal flora disorder and is easy to further induce coronary artery disease,so it should be paid close attention to in clinical diagnosis and treatment.

关 键 词：儿童 川崎病 冠状动脉病变 肠道菌群 

分 类 号：R725.4[医药卫生—儿科]