督脉灸改善中晚期肿瘤患者化疗期间生活质量和免疫功能的临床疗效观察  

Clinical efficacy observation on improving quality of life and immune function of patients with advanced tumor during chemotherapy with Du meridian moxibustion

作　　者：张琦 张孝刚 殷世丽 周朝娟 ZHANG Qi;ZHANG Xiaogang;YIN Shili;ZHOU Chaojuan(The Second Clinical Medical College,Guizhou University of Traditional Chinese Medicine,Guizhou,Guiyang 550000,China;Department of Tumor,Zunyi Hospital of Traditional Chinese Medicine,Guizhou,Zunyi 563000,China)

机构地区：[1]贵州中医药大学第二临床医学院,贵州贵阳550000 [2]贵州省遵义市中医院肿瘤科,贵州遵义563000

出　　处：《中国医药科学》2025年第6期97-100,共4页China Medicine And Pharmacy

基　　金：贵州中医药大学研究生创新计划自然科学项目(YCXZR2021015)。

摘　　要：目的 观察督脉灸改善中晚期肿瘤患者化疗期间生活质量和免疫功能的临床疗效。方法 选取2022年1月至2023年10月于遵义市中医院肿瘤科住院治疗并符合纳入标准的中晚期恶性肿瘤化疗患者60例,使用随机数表法分为治疗组(30例)、对照组(30例);治疗组在对照组基础上联合督脉灸治疗,对照组仅行常规化疗及对症支持治疗。比较两组患者治疗前及治疗2、4个周期后的生活质量评分和NK细胞占比、T细胞占比(CD3^(+)、CD4^(+)、CD8^(+))、B细胞占比(CD19^(+)、CD20^(+))及CD4^(+)/CD8^(+)比值。结果 治疗2、4个周期后,两组的生理状况、情绪状况、功能状况评分均高于治疗前,差异有统计学意义(P<0.05);治疗组的生理状况、情绪状况、功能状况评分均高于对照组,差异有统计学意义(P<0.05)。治疗组的CD8^(+)T细胞占比、CD19^(+)B细胞占比均低于治疗前,CD4^(+)T细胞占比和CD4^(+)/CD8^(+)比值均高于治疗前,差异有统计学意义(P<0.05);CD3^(+)T细胞占比及CD20^(+)B细胞占比与治疗前比较,差异无统计学意义(P>0.05)。对照组的CD3^(+)T细胞占比、CD4^(+)T细胞占比、CD8^(+)T细胞占比及CD19^(+)B细胞占比均低于治疗前,NK细胞占比高于治疗前,差异有统计学意义(P<0.05);CD4^(+)/CD8^(+)比值及CD20^(+)B细胞占比与治疗前比较,差异无统计学意义(P>0.05)。治疗组的NK细胞占比、CD3^(+)T细胞占比、CD4^(+)T细胞占比及CD4^(+)/CD8^(+)比值均高于对照组,差异有统计学意义(P<0.05)。两组的CD8^(+)T细胞占比、CD20^(+)B细胞占比比较,差异无统计学意义(P>0.05)。结论 督脉灸可提高中晚期肿瘤患者化疗期间的免疫功能,能够提升中晚期肿瘤患者的生活质量,值得推广应用。Objective To observe the clinical efficacy on improving quality of life(QoL)and immune function of patients with advanced tumor during chemotherapy with Du meridian moxibustion.Methods A total of 60 patients with advanced malignant tumor undergoing chemotherapy and hospitalized in the Department of Tumor of Zunyi Hospital of Traditional Chinese Medicine and met the inclusion criteria from January 2022 to October 2023 were selected and divided into the treatment group(n=30)and the control group(n=30)according to the random number table method.The treatment group was given Du meridian moxibustion on the basis of the control group,while the control group only was given conventional chemotherapy and symptomatic support treatment.The QoL scores and the proportions of NK cells,T cells(CD3^(+),CD4^(+),CD8^(+)),B cells(CD19^(+),CD20^(+)),and the CD4^(+)/CD8^(+)ratio between the two groups of patients before treatment and after 2 or 4 treatment cycles were compared.Results After 2 or 4 treatment cycles,the scores of physiological status,emotional status and functional status of the two groups were all higher than those before treatment,with statistically significant differences(P<0.05).The scores of physiological status,emotional status and functional status in the treatment group were all higher than those in the control group,with statistically significant differences(P<0.05).The proportions of CD8^(+)T cells and CD19^(+)B cells in the treatment group were all lower than those before treatment,while the proportions of CD4^(+)T cells and CD4^(+)/CD8^(+)ratio were all higher than those before treatment,with statistically significant differences(P<0.05).There were no statistically significant differences in the proportions of CD3^(+)T cells and CD20^(+)B cells between before and after treatment(P>0.05).The proportions of CD3^(+)T cells,CD4^(+)T cells,CD8^(+)T cells and CD19^(+)B cells in the control group were all lower than those before treatment,while the proportions of NK cells were higher than those before treatment,wi

关 键 词：督脉灸 肿瘤 化疗 生活质量 免疫功能 

分 类 号：R273[医药卫生—中西医结合]